| Background Chronic obstructive pulmonary disease is a common and multiple disease. It is high rate of hospitalization and mortality,which is harmful to people’s health,quality of life. Exacerbations and complications of COPD bring a heavy financial burden to patients, their families and the community. Therefore, it is a major and difficult task for clinicians in terms of early detection and scientific treatment of COPD. Currently, pulmonary function test is still used by clinicians to determine whether there is clinical airflow limitation. But the lung volume and airflow will be affected with age.The diagnosis of COPD with FEV1/FVC will result in misdiagnosis or over-diagnosis for somebody. In addition pulmonary function test also requires the cooperation of patients, when the condition of people is more serious, they can not complete the test. To make up for these shortcomings, scholars are trying to explore biomarkers of COPD that can be obtained and tested easily,and these biomarkers are used for diagnosing COPD and monitoring changes in the disease. Recently, serum/ plasma biomarkers of COPD become a hot topic.Objective To explore the changes and clinical significances of serum SP-D, hs-CRP and plasma fibrinogen in the patients with chronic obstructive pulmonary disease.Methods In this study,30 patients were in AECOPD group, including 25 males and 5 females. Their ages were (68.40 ±8.97)years old, smoking index were 482.97± 404.95.Ten patients were in stable COPD group, including 8 males and 2 females. Their ages were (65.40±9.42)years old, smoking index were 405..90±245.54. There were 30 cases in healthy control group, including 22 males and 8 females.Their ages were (67.47±6.57)years old, smoking index were 391.73±342.16. there were no significant differences among three groups about age, gender, smoking index. We respectively measured levels of serum SP-D, hs-CRP in three groups, and compared their differences. We also measured levels of plasma fibrinogen in AECOPD group and stable group, and compared the difference between them. In addition,the levels of FEV1%pred and FEVi/FVC in AECOPD group and stable COPD group were measured, then analyzed correlations between levels of serum SP-D% hs-CRP, plasma fibrinogen and FEV,%pred, FEV,/FVC.Results (1) Levels of serum SP-D in AECOPD group, stable COPD group, healthy control group were (21.90±.89), (12.49±.52), (8.07±.03) ng/mL, respectively. Serum levels of SP-D in the AECOPD group were higher than those in stable COPD group and healthy control group, the differences were both statistically significant (P< 0.05); Serum levels of SP-D in the stable COPD group were higher than those in healthy control group, the difference was statistically significant (P< 0.05). (2) Levels of serum hs-CRP in AECOPD, stable COPD group, healthy control group were(14.23 ±7.00), (3.19±3.04), (1.06±1.09) mg/L, respectively. Serum levels of hs-CRP in the AECOPD group were higher than those in stable COPD group and healthy control group, the differences were both statistically significant (P<0.05); Comparison between stable COPD group and healthy control group about serum levels of hs-CRP had no significant difference (P> 0.05).(3) The levels of plasma Fbg in AECOPD group and stable COPD group were(4.27±1.15),(3.38±1.26)g/L, respectively. The levels of plasma Fbg in the AECOPD group were higher than those in stable COPD group, the difference was statistically significant (P< 0.05).(4) The levels of FEV^/o pred,FEV1/FVC (%) in the AECOPD group were55.30+20.57,52.27+12.02, respectively. The levels of FEV1% pred,FEV1/FVC (%) in the stable COPD group were 56.63±17.38,65.36±4.09, respectively. Levels of FEV1/FVC in the stable COPD group were higher than those in AECOPD group, the difference was statistically significant (.P< 0.05). Comparison between AECOPD group and stable COPD group about levels of FEV1% pred had no significant difference (P> 0.05). (5)The correlation analysis showed that levels of serum SP-D, hs-CRP and plasma fibrinogen in the two COPD groups were no correlated with FEV1% pred and FEVi/FVC (P> 0.05)Conclusions The levels of serum SP-D, hs-CRP and plasma fibrinogen can be as good indicators in the diagnosis and condition monitoring of COPD, Combined detection of these biomarkers can increase the sensitivity and specificity, which also will be significant for improving prognosis. |
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