Clinical Effect Of Lujiao BuGu Recipe Combined With Bisphosphonate On Postmenopausal Osteoporosis Of Kidney-yang Deficiency Type

Objective:To observe the therapeutic effect of Lujiao Bu Gu Recipe combined with bisphosphonate sodium in treating postmenopausal osteoporosis of Kidney-Yang deficiency type,and to further confirm the clinical effect of the principle of warming kidney and strengthening yang in treating Postmenopausal osteoporosis of Kidney-Yang deficiency type.Methods: 30 cases of Postmenopausal osteoporosis patients with renal Yang deficiency who met the criteria were divided into treatment group and control group by random table method.In the control group,calcium D,Alendronate and Bisphosphonate were given to the control group,and the treatment group was treated with antler psoralic formula on the basis of the medicine used in the control group.Before and 3 months after treatment,the clinical symptoms and bone turnover indexes were analyzed and compared,and the Bone Mineral Density(BMD)was examined before treatment and 12 months after treatment,and the changes of Bone Mineral Density(BMD)were observed.The clinical third-party blindness method was used to establish the scheme blindness.Results:(1)The total effective rate of the treatment group was 90%,the total effective rate of the control group was 66.7%,the total effective rate of the treatment group was higher than that of the control group,and there was significant difference between the two groups(P < 0.05).The results showed that the treatment group had better curative effect on Postmenopausal Osteoporosis of Kidney-Yang deficiency type.(2)After 3 months of treatment,the total score of clinical symptoms in the two groups was lower than that before treatment.In the treatment group,compared with the control group,the total score of clinical symptoms in the treatment group was better than that in the control group,which improved the cold pain of the waist and back,softness and weakness,bent back and hunchback,was afraid of cold and warm,and had cramps.The total score of TCM symptoms is better than that of the control group.(3)Bone Mineral Density(BMD)of the two groups(lumbar vertebra,left hip joint)was increased after 12 months treatment,and there was significant difference between the treatment group and the control group after 12 months treatment(P < 0.05),which indicated that the treatment group could improve the bone mineral density more effectively(P < 0.05).(4)The bone turnover marker β-CTX in the two groups was lower than that before treatment for 3 months,and there was a significant difference between the two groups at 3 months after treatment,which indicated that the treatment group could improve the bone turnover markers more effectively.Conclusion: In the treatment group,the Bone Mineral Density(lumbar spine,hip joint),bone metabolism markers and clinical symptoms of the patients were better than those in the control group.The results showed that Lujiao Bu Gu recipe was effective in improving the symptoms of Kidney Yang deficiency,such as low back cold pain,weakness and weakness,bending back,fear of cold and warm,cramps and so on,improved bone mineral density,prevented bone mass loss,and adjusted bone turnover rate,and no adverse reaction was observed.