| Objective:Observe the clinical efficacy and safety of Bushen Tongluo prescription in the treatment of knee osteoarthritis(KOA)pain with syndrome of.liver and kidney deficiency and blood stasis,and explore its possible mechanism for the treatment of KOA pain,to provide experimental basis for the treatment of osteoarthritis pain with traditional Chinese medicine.Method:According to the inclusion and exclusion criteria,a total of 60 patients with KOA with liver and kidney deficiency and blood stasis syndrome were divided into treatment group and control group according to random number table method,30 cases in each group.The control group was orally administered meloxicam tablets,l tablet once a day,and the Traditional Chinese medicine wet compress treatment was applied for about 30 minutes;the treatment group was supplemented with the Bushen Tongluo prescription on the basis of the control group,1 dose per day,divided into two times.The treatment cycle for both groups was 4 weeks.The basic information before and after treatment of the control group and the treatment group was recorded(including name,gender,age,course of disease,current drug use,past medical history and past drug use,and the patient's general life status,etc).Record the VAS score,WOMAC score,quantitative score of Chinese medicine symptoms and clinical laboratory examination(including blood routine examination,ESR,CRP,liver and kidney function)before and after treatment in both groups,and use ELISA to detect the content of BK,TRPA1 and CGRP in the serum of patients before and after treatment.Result:1.Basic situation:The control group finally included 26 cases,including 9 males,accounting for 34.62%,and 17 females,accounting for 65.38%.The average age was 64.62 ± 5.93 years,the average course was 5.70±2.50 years,and the average BMI was 25.08± 2.06 kg/m2.The treatment group finally included 27 patients,including 9 males,accounting for 33.33%,and 18 females,accounting for 66.67%,with an average age of 61.93 ± 5.67 years,an average duration of 5.47 ± 3.21 years,and an average BMI of 25.70 ± 1.85 kg/m2.After statistical analysis,the differences in gender,age,course of disease,and body mass index between the two groups were not statistically significant(P>0.05)and were comparable;2.VAS score:the difference in VAS score between the two groups before treatment There was no statistical significance(P>0.05)and it was comparable.Compared with the same group,the VAS scores between the two groups before and after treatment were significantly reduced(P<0.05),the difference was statistically significant.Compared between the two groups,the VAS score of the treatment group decreased more significantly than the control group after treatment(P<0.05),the difference was statistically significant;3.WOMAC score,quantitative score of Chinese medicine symptoms:WOMAC score and quantitative score of Chinese medicine symptoms before treatment,The difference in scores was not statistically significant(P>0.05)and it was comparable.Compared within the same group,the WOMAC score and the quantitative score of Chinese medicine symptoms between the two groups before and after treatment were significantly reduced(P<0.05),and the difference was statistically significant.Compared between the two groups,the WOMAC score and the quantitative score of Chinese medicine symptoms after treatment in the treatment group were more significantly lower than those in the control group(P<0.05),the difference was statistically significant;4.Before treatment,the contents of BK,TRPA1 and CGRP were not significantly different(P>0.05),and were comparable.Compared within the group,the contents of BK,TRPA1 and CGRP in both groups decreased significantly after treatment(P<0.05).The difference within the group was statistically significant.The content of BK,TRPA1 and CGRP decreased more than the control group(P<0.05),the difference was statistically significant.During the experiment,there were no obvious abnormalities in blood routine examination,CRP,ESR,liver and kidney function,and no adverse events were reported.Conclusion1.By applying Bushen Tongluo prescription to treat KOA patients with liver and kidney deficiency and blood stasis syndrome,compare the VAS score,WOMAC score and quantitative score of Chinese medicine symptoms before and after treatment,andand it was found that VAS score,WOMAC score and quantitative score of Chinese medicine symptoms all decreased significantly after treatment,suggests that Bushen Tongluo prescription has a significant effect on KOA pain.In addition,Bushen Tongluo prescription also plays a role in relieving physical discomfort and improving the quality of life.Bushen Tongluo prescription has no obvious adverse reactions in the treatment of KOA and has high safety.2.By applying Bushen Tongluo prescription to treat patients with liver and kidney deficiency and KOA with blood stasis and obstruction syndrome,compare the changes of serum BK,TRPA1 and CGRP levels before and after treatment,and find that serum BK,TRPA1 and CGRP levels are significantly reduced after treatment,Suggesting that Bushen Tongluo prescription may achieve therapeutic effect by inhibiting pain sensitization. |
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