Professor Tang Xudong's Experience Mining And Network Pharmacology Research On The Treatment Of Gastroesophageal Reflux Disease

Objective:Based on the ancient and modern medical case cloud platform,using data mining technology,to comprehensively summarize and analyze the characteristics and experience of Professor Tang Xudong’s medication in the treatment of gastroesophageal reflux disease,and to further mine and analyze the mechanism of the commonly used drugs of Professor Tang Xudong by relying on the analysis method of network pharmacology.Methods:from October 2017 to October 2019,276 cases of gastroesophageal reflux disease(GERD)were collected from Professor Tang Xudong’s clinic.The general information of patients’ name,gender,age and other diagnosis and treatment information such as engraved symptom,diagnosis of traditional Chinese medicine,syndrome of traditional Chinese medicine,diagnosis of western medicine,prescriptions and examination results were recorded and saved.Input these saved information into the medical record analysis software of ancient and modern medical record cloud platform.The collected medical record information is screened and processed in a unified way to make it meet the requirements of standardization.After that,frequency analysis,association analysis,cluster analysis and complex network analysis are carried out,and the research methods of network pharmacology are used to explore the possible mechanism of commonly used drugs.Results:among the 182 patients with gastroesophageal reflux disease,77 were male and 105 were female.The patients aged 40-49 accounted for the most.The most common symptoms of the patients were belching,and other main symptoms included hunger,NACO,acid reflux,swelling after eating,etc.The most common TCM syndrome diagnosis of the patients was disharmony of liver and stomach(25.81%).The other main TCM syndrome diagnosis of the patients included spleen deficiency and Qi Stagnation(20.44%),spleen deficiency and dampness Stagnation(16.62%),liver depression and spleen deficiency(5.15%),spleen deficiency and dampness stagnation(3.68%).Professor Tang Xudong’s most commonly used medicine is Amomum villosum.Other commonly used traditional Chinese medicine mainly includes fried licorice,yanhusuo,cuttlebone,tangerine peel,Coptis,Fructus aurantii,dangshen,bupleurum,fried Shenqu,white peony,Peilan,Poria,perilla stem,fabianxia,fried Atractylodes Rhizoma,raw Astragalus,fried Atractylodes Rhizoma,dried ginger,Fructus aurantii,etc.It can be seen from the meridian tropism that the most common meridian tropism is the spleen meridian of foot Taiyin,followed by the stomach meridian of Foot Yangming,lung meridian of hand Taiyin,liver meridian of foot Jueyin,kidney meridian of foot Shanyin,heart meridian of hand Shaoyin,gallbladder meridian of foot Shaoyang,etc.From the perspective of drug four Qi,the most common drug four Qi belongs to temperature,followed by temperature,peace,micro cold,cold,heat,etc.From the perspective of patients’five tastes,the most common five tastes belong to pungent,followed by bitter,sweet,sour,astringent,salty and so on.After that,we use the method of network pharmacology to study the common drugs,and use the cycloscape to visualize the information.Research conclusion:according to the analysis results,Professor Tang Xudong’s theory of Tongjiang is reflected in the treatment of gastroesophageal reflux disease.The most common efficacy of traditional Chinese medicine is to relieve pain.Other main efficacy of traditional Chinese medicine are:clearing away heat and drying dampness,drying dampness and resolving phlegm,warming the spleen to stop diarrhea,eliminating dampness and opening up the stomach,regulating qi and fetus,purging fire and detoxifying,supplementing qi and pulse,nourishing the spleen and stomach,promoting blood circulation,promoting Qi,regulating qi width and so on.