| Objective:To explore the clinical effect of "Wenyang Lishui Prescription" combined with external application in the treatment of Breast Cancer-Related Lymphedema,and to provide an effective TCM treatment plan for the treatment of edema.Methods:The main purpose of this experiment is to apply Wenyang Lishui prescription combined with external application to treat upper limb lymphedema after breast cancer operation,and to evaluate the effect of intervention on arm circumference and breast cancer related lymphedema symptoms.Patients who meet the inclusion criteria in the Department of Oncology,Oriental Hospital of Beijing University of traditional Chinese Medicine from January 2019 to December 2019 were selected.Randomly and double-blindly divided into treatment group and control group,each group of 24 people,treatment group(experimental drug routine functional exercise),control group(placebo routine functional exercise).To study the changes of upper limb arm circumference and breast cancer-related lymphedema symptoms between the two groups before and after treatment,and to explore the efficacy of Wenyang Lishui prescription combined with external application in the treatment of upper limb lymphedema and upper limb discomfort after breast cancer operation.to provide a treatment scheme for traditional Chinese medicine to participate in the standardized treatment of lymphedema after breast cancer operation.Results:1.Enrollment:clinical observation was completed in 43 cases at the end of the study,including 22 cases in the intervention group and 21 cases in the control group.There was no significant difference in baseline examination(age,surgical site,mode of operation,number of lymph node dissection,pathological type,tumor stage,radiotherapy and chemotherapy,arm circumference,BCLE-SEI score)between the two groups.2.In terms of the measured value of the circumference of the affected arm:after the intervention,the circumference of the affected arm in the two groups was smaller than before,and there was a statistical difference before and after the intervention group(P<0.05),but there was no statistical difference in the control group(P>0.05).There was no significant difference between the intervention group and the control group(P>0.05).According to the results of repeated measurement analysis of variance,the final time group P<0.05,indicating that the difference of arm circumference measured at different time points is statistically significant,and the time*group group P>0.05,indicating that there is no interaction between time and grouping,and the effect of time factor does not have statistical difference between the two groups.3 In terms of breast cancer-related lymphedema symptom experience index:Total scores:at the 3rd and 5th day of intervention,the total scores of the two groups were not statistically significant;At the 10th day of intervention,there was a statistical difference in the total score of the scale between the two groups(P<0.05).Comparison of the incidence of lymphedema symptoms:on the 3rd day of intervention,the results of 2 test indicated that the difference in the incidence of "limb weakness" between the intervention group and the control group was statistically significant(P<0.05).On the 5th day of intervention,the results of 2 test indicated that the incidence of "stiffened,rough or thickened limb skin"(P<0.05),"numbness"(P<0.05),"limb fatigue"(P<0.05)and "limb weakness"(P<0.05)in the intervention group and the control group were statistically significant.Intervention in 10 days,chi square test results suggest intervention group and control group in the two groups in the "stiff limb"(P<0.05),"limb skin hardens,rough or thickening"(P<0.05),"sore limb pain/home"(P<0.05),"limb numbness"(P<0.05),"limb fatigue"(P<0.05),"limb weakness"(P<0.05)the difference in incidence was statistically significant.Lymphedema-related symptom distress score and scores in all dimensions:on the 3rd day of intervention,there was no statistical difference between the two groups in the score of lymphedema-related symptom distress and scores in all dimensions(P>0.05).On the 5th day of the intervention,the emotional score of the intervention group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 10 days of intervention,the scores of symptom disturbance,social dimension,emotional dimension and sleep dimension in the intervention group were all lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:This experimental study shows that the treatment method of Wenyang Lishui prescription combined with external application can reduce the arm swelling,improve the disturbance of edema symptoms,reduce the disturbance of edema from social,emotional and sleep dimensions,and improve the quality of life of patients. |
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