| Purpose:This article compares the clinical data of patients with type 2 diabetes who have hyperuricemia or not,to Analysis the relationship between HUA and Diabetic Kidney Disease,Diabetic Retinopathy,and Diabetic Peripheral Neuropathy.To explore whether SUA is a risk factor for DR,DPN and DKD.In addition,the relationship between HUA and the distribution of TCM syndromes in diabetic patients was discussed to provide a reference for the clinical treatment of TCM syndrome differentiation.Material and method: Collected the patients with T2 DM who were hospitalized in Department of Endocrine in Liaoning Hospital of TCM from 2019 July to October 2019.According to whether SUA is greater than 420μmol/L,the patients were divided into HUA group and NUA group.Compare of patient’s age,course,body mass index,Waist circumference,Fasting Plasma Glucose,Fasting C Peptide,glycosylated hemoglobin A1,c-reactive Protein,CRP,blood lipid,renal function,urine p H value and visceral fat area,distribution patterns of TCM syndromes between two groups.The differences in the number of patients with obesity,hypertension,metabolic syndrome,DR,DPN and DKD were compared in the two groups.Divided paitients into Q1,Q2,Q3,and Q4 groups with 25% equal width according to the SUA level,and analyzed the differences in the proportion of DR,DKD,and DPN among the four groups of patients.Patients were divided into A1(ACR <30mg/g),A2(30mg/g≤ACR <300mg /g),and A3(300mg/g≤ACR)three groups according to the urine albumin to Creatinine Ratio stage and compared differences in SUA levels in those groups.Classification data were expressed by composition ratio and percentage,and test by chi-square test or Fisher test;measurement data were expressed by mean ± standard deviation.Those conforming to normal distribution were tested by T test,while those not conforming to normal distribution were tested by non-parametric test.Logistic regression was used to investigate whether SUA was a risk factor for DR,DKD and DPN.Results: 1.Data of 229 patients were finally included,including 52(22.7%)patients with HUA,33(14.4%)patients with DR,112(48.9%)patients with DPN,and 76(3.2%)patients with DKD.2.The SUA level of DKD patients was higher than that of NDKD patients,and the difference was statistically significant(P<0.05).There was no statistically significant difference in SUA levels between DR and NDR patients and between DPN and NDPN patients(P>0.05).The number of patients with DKD in Q1,Q2,Q3 and Q4 group was 20.7%,26.3%,37.9% and 48.2%,with statistical differences(χ2=11.591,P<0.01),and there had an inter-group difference between group Q1 and group Q4(P<0.05).There was no statistical difference in the number of DR patients and DPN patients in the four groups(P>0.05).There were statistically significant differences in SUA levels between groups A1,A2 and A3(P<0.05),and there were inter-group differences between groups A1 and A3 and between groups A2 and A3(P<0.05).Logistic regression analysis showed that course of disease [OR=1.008,95%CI(1.004,1.013),P=0.002] and SUA [OR= 1.068,95%CI(1.025,1.113),P=0.000] were risk factors for DKD.Duration [OR = 1.072,95%CI(1.023,1.123),p=0.004] was risk factor for DR.Course of disease is also a risk factor for DPN [OR = 1.108,95%CI(1.062,1.155),p=0.000].3.The proportion of Qi-Yin deficiency with blood stasis in NUA group was 70.1%,the proportion of dampness-heat trapping spleen with blood stasis was 24.3%,the proportion of Qi-Yin deficiency and blood stasis was 3.4%,and the proportion of Yin and Yang deficiency with blood stasis was 2.3%.The proportion of Qi-Yin deficiency and blood stasis in HUA group was 46.2%,the proportion of dampness-heat trapping spleen with blood stasis was 44.2%,the proportion of qi-Yin deficiency and blood stasis was 1.9%,and the proportion of Yin and Yang deficiency and blood stasis was 7.7%.The proportion of dampness-heat trapping spleen with blood stasis in HUA group was higher than that in NUA group(P<0.05).4.The BMI,WC,FCP,Three acids Glyceride,Creatinine,ACR,and visceral fat area levels in HUA group was higher than the NUA group(P <0.05),but the high density lipoprotein-Cholesterol and urine p H in The HUA group was lower than the NUA group(P <0.05).There are no significant statistical differences in age,course of disease,FPG,CRP,Hb A1 c,Total Cholesterol,low density lipoprotein,and creatinine clearance rate between two groups(P >0.05).The proportion of different genders between the two groups have no statistical difference(P> 0.05).HUA group had more patients with obesity,dyslipidemia,hypertension and metabolic syndrome than NUA group(P <0.05).Conclusion: 1.T2 DM patients with HUA are more likely to have the syndrome type of dampness-heat trapping spleen with blood stasis 2.High level of SUA is a risk factor for DKD,but not for DR and DPN.3.HUA is helpful for the Screening and prevention of obesity,dyslipidemia,hypertension and metabolic syndrome in T2 DM patients. |
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