Analysis And Research On Correlative Factors Of Type 2 Diabetes Microangiopathy And TCM Syndrome

Objective: In patients with type 2 diabetes microvascular lesion of general information collection,related to the physical and chemical index and dialectical classification,analysis and study microvascular lesions in patients with type 2diabetes and the related clinical indicators,the relationship between dialectical traditional Chinese medicine and the law,to prevent and delay the onset of type 2diabetes microvascular lesions provide certain clinical basis.Methods:A retrospective analysis was conducted on the related indexes of 326 patients with type 2 diabetes who were admitted to the Department of Endocrinology of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine(Yunnan Hospital of Traditional Chinese Medicine)from January 2020 to December2020 and who met the inclusion criteria.General information of patients was collected,including name,admission number,gender,age,course of disease,body mass index(BMI)and other basic information.Laboratory indicators,including: fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA IR)and uric acid(UA),serum creatinine(CR),urine trace albumin(m ALB),urine creatinine(UCR),cholesterol(CHOL),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),sugar,sanlian(FPG,FRA,Hb A1c),ophthalmology consultation,TCM four diagnostic data,etc.,retrospective statistical analysis.Results: 1.Results of general data analysis: Among the 326 patients in this study,there were 174 males and 152 females.According to the chi-square test,there was no statistical significance between gender and type 2 diabetic microangiopathy(T2DMAP)group and non-type 2 diabetic microangiopathy(NT2DMAP)group(P >0.05),suggesting that age was not related to the occurrence of T2 DMAP.2.The duration,FINS,HOMA-IR,MALB,Cr and UA of T2 DMAP and NT2 DMAP groups did not conform to the normal distribution by statistical analysis.The results of ranksum test showed that FINS of the two groups was not statistically significant(P >0.05).The P values of disease duration,m ALB and Cr were less than 0.01,which was statistically significant.The P value of UA less than 0.05 was statistically significant.Duration,m ALB,Cr and u A were correlated with T2 DMAP,but not with FINS.3.After statistical analysis,the age,BMI,CHOL,TG,HDL-C,LDL-C,empty FPG,FRA,Hb A1 c,UCR of the T2 DMAP and NT2 DMAP groups are in accordance with the normal distribution after statistical analysis,and the independent sample t test is used.The result Show: The P value of FPG is less than 0.01,which is statistically significant;the P value of Hb A1 c is less than 0.05,which is statistically significant.The age,BMI,CHOL,TG,HDL-C,LDL-C,FPG,FRA,UCR of the two groups The comparison was not statistically significant(P>0.05).FPG and Hb A1 c are related to the occurrence of T2 DMAP,but not related to age,BMI,CHOL,TG,HDL-C,LDL-C,FPG,FRA,UCR.4.Regarding whether combined with microvascular disease as the dependent variable,the statistically significant variables(disease course,FPG,Hb A1 c,m ALB,Cr,UA,HOMA-IR,TCM syndrome type)are used as independent variables,and the backward method is used to fit the two Class multivariate Logistic regression model.Test results: The P value of disease course,FPG,m ALB,Cr is less than 0.05,which is statistically significant.Therefore,the risk factors for DMAP in T2 DM patients are the course of disease,FPG,m ALB,and Cr.5.209 cases of T2 DMAP patients have the following medical syndromes: 72 cases of Qi and Yin deficiency(34.45%),64 cases of Qi and Yin deficiency and blood stasis syndrome(30.62%),39 cases of spleen and stomach damp-heat syndrome(18.66%),liver and kidney 24 cases(11.48%)of Yin deficiency syndrome and 10 cases(4.78%)of lung-heat and body-injury syndrome;the course of disease was divided into three groups: course of disease <5 years,5 ≤ course of disease <10years,and course of disease≥10 years,each type of syndrome Comparison and analysis with the disease course group showed that the results were statistically significant(P<0.01).Patients with Qi and Yin Deficiency Syndrome and Qi and Yin Deficiency Syndrome with Blood Stasis had a longer course.Divide Hb A1 c into 3 groups: Hb A1c<7%,7%≤Hb A1c<10%,Hb A1 c ≥ 10%,and compare and analyze each syndrome type with Hb A1 c grouping,and the results are statistically significant(P=0.028<0.05).Conclusion:1.The occurrence of T2 DMAP is affected by multiple factors.Among them,the course of disease,FPG,Hb A1 c,HOMA-IR,m ALB,UA,and CR are related factors for the occurrence of T2 DMAP,while the course of disease,m ALB,and CR are risk factors for T2 DMAP in patients with T2 DM.Gender,age,BMI,CHOL,TG,HDL-C,LDL-C have nothing to do with the occurrence of T2 DMAP.2.Distribution of TCM syndrome types: Qi and Yin deficiency syndrome and Qi Yin deficiency and blood stasis syndrome are the top two syndrome types in the T2 DMAP group.Patients with Qi and Yin deficiency syndrome and Qi and Yin deficiency and blood stasis syndrome have a longer course of disease.Blood sugar control is not ideal.3.In the process of prevention and treatment of T2 DMAP,due to the active control of risk factors,plus the dialectical treatment of Chinese medicine,more reasonable and complete intervention and treatment of T2 DMAP.