| Purpose:To study whether patients with family history of liver cirrhosis have higher risk of liver cirrhosis and which syndrome type of such patients is more likely to progress to liver cirrhosis,and to explore the correlation laws between family history and other relevant physical and chemical indicators and prognosis of patients,so as to provide clinical guidance and objective basis for preventing the progress of chronic hepatitis B to liver cirrhosis.Material and Method:To collect information on the diagnosis and treatment of 500 patients with chronic hepatitis B or chronic post hepatitis B Cirrhosis who have family history in the outpatient department of the Liaoning University of Traditional Chinese Medicine Statistical analysis was used to summarize the prognosis of patients with family history of hepatitis B and which indicators are closely related.Results:1.490 patients,198 patients with liver cirrhosis and 292 patients with chronic hepatitis B were collected.There are 6 types of liver cirrhosis: liver and spleen blood stasis,qi stagnation and dampness obstruction,spleen and kidney yang deficiency,cold and dampness trapping spleen,dampness and heat accumulation,liver and kidney yin deficiency.There are 6 types of chronic hepatitis B: liver depression and spleen deficiency,spleen deficiency and dampness excess,blood stasis blocking collaterals,spleen and kidney yang deficiency,liver and gallbladder damp heat,liver and kidney yin deficiency.2.The number of patients with liver cirrhosis aged 51-60 was 66,accounting for 33.33%,followed by 58 patients aged 41-50,accounting for 29.30%;The number of chronic hepatitis B patients aged 31-40 is 100,accounting for 34.25%.After chi-square test,the P values were all less than 0.05,with statistical significance.3.patients with chronic hepatitis b ≤30 years old have a large proportion of damp-heat in liver and gallbladder,liver depression and spleen deficiency,and spleen deficiency and dampness-excess syndrome,accounting for 25.81%,27.42%,27.42% and close to each other respectively.patients aged 31-40 years old have the highest proportion of spleen deficiency and dampness-excess syndrome,accounting for 24.68%,28.57% of patients aged 41-50 years old,35.56% of patients aged 51-60 years old,and 62.5% of patients aged > 60 years old have the highest proportion of spleen-kidney deficiency syndrome.After chi-square test,the P values were all less than 0.05,with statistical significance.The number of patients with liver depression and spleen deficiency is up to 71,accounting for 24.32%.Most of these patients are aged 31-40 years,followed by 70 patients with spleen deficiency and dampness excess,accounting for 23.97%,and most of them are also aged 31-40 years.4.liver cirrhosis patients aged 31-40 years old had the most 13 cases of qi stagnation and dampness retention syndrome,with a proportion of 33.33%(chi-square test: p=0.000<0.05,with statistical significance);patients aged 41-50 years old had the most 23 cases of qi stagnation and dampness retention syndrome,with a proportion of 39.66%,liver and spleen blood stasis followed by 18 cases,with a proportion of 31.03%(chi-square test: p=0.000<0.05,with statistical significance).Up to 28 patients aged 51-60 had liver and spleen blood stasis syndrome,accounting for 42.42%(chi-square test: p=0.000<0.05,with statistical significance);up to 10 patients aged > 60 had spleen and kidney yang deficiency syndrome,accounting for 41.67%(chi-square test: p=0.000<0.05,with statistical significance).Comprehensive observation of liver and spleen blood stasis syndrome patients up to 55 cases,the proportion is 27.78%,most of these patients are distributed in 51-60 years old,followed by 45 cases of qi stagnation and dampness resistance syndrome patients,the proportion is22.73%,most of these patients are distributed in 41-50 years old.5.The gender distribution of chronic hepatitis B syndrome is tested by Chi-square test P =0.735 > 0.05,which is not statistically significant.The gender distribution of cirrhosis syndrome is tested by Chi-square test P = 0.515 > 0.05,which is also not statistically significant.6.among the cirrhotic population,the proportion of patients with family history of cirrhosis is93.43%,which is statistically significant by chi-square test p=0.000<0.05.7.The proportion of patients with liver cirrhosis who had family history of liver cirrhosis and received antiviral therapy was 38.32%,which was less than that of patients without liver cirrhosis.Among people with family history of liver cirrhosis and liver cirrhosis,the proportion of patients who have received antiviral therapy is 34.59%,which is also less than the number of patients without liver cirrhosis.chi-square test shows that p=0.000<0.05,which has statistical significance.8.Only 13 of 162 patients with no family history of liver cirrhosis,accounting for 8.02%.The number of patients without family history of liver cirrhosis,whether antiviral or not,is roughly the same,while the proportion of patients with liver cirrhosis receiving antiviral therapy is 5.80%,and the proportion of patients without antiviral therapy is 11.86%.9.Patients with liver cirrhosis and family history had the most liver and spleen blood stasis syndrome,accounting for 29.7%,followed by qi stagnation and dampness retention syndrome,accounting for 22.7%;The patients with liver cirrhosis but no family history of liver cirrhosis had the most spleen-kidney yang deficiency syndrome,accounting for 46.2%.Among the patients without liver cirrhosis but with family history of liver cirrhosis,the number of patients with blood stasis blocking collaterals was the largest,accounting for 28.0%,followed by liver depression and spleen deficiency,accounting for 24.5%.The patients with liver depression and spleen deficiency were the most common among the patients without liver cirrhosis and family history of liver cirrhosis,accounting for 24.3%,followed by spleen deficiency and dampness excess,accounting for 24.0%.10.The ratio of the incidence of liver cirrhosis with family history to that without family history is 10.073,the ratio of the incidence of liver cirrhosis with one grade increase in age is1.943,The ratio of non-antiviral to antiviral cirrhosis is 3.553,the ratio of AST abnormality to AST normal liver cirrhosis is 3.762,and the ratio of GGT abnormality to GGT normal liver cirrhosis is 6.619.The ratio of ALP abnormality to liver cirrhosis with normal ALP is 3.254,the ratio of TBIL abnormality to liver cirrhosis with normal TBIL is 6.635,the ratio of IBIL abnormality to liver cirrhosis with normal IBIL is 3.635,the ratio of A/G abnormality to liver cirrhosis with normal A/G is 5.236,and the ratio of AFP abnormality to liver cirrhosis with normal AFP is 6.619.Conclusion:1.liver sclerosis has obvious family susceptibility,and is the most susceptible to blood stasis syndrome.2.The use of antiviral drugs can significantly reduce the incidence of liver cirrhosis.3.Family history,age,antiviral status,AST,GGT,ALP,TBIL,IBIL,A/G and AFP are the ten risk factors for the progression of chronic hepatitis B patients to cirrhosis,of which the family history of cirrhosis is the largest risk factor. |
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