Analysis Of Serum Thyroid Hormone Levels In Chronic Hepatitis B Patients And Hepatitis B Patients With Cirrhosis

Objective:We collected the 287 cases of chronic hepatitis B patients and hepatitis B patients with liver cirrhosis in Jincheng Coal General Hospital from 2002 to 2009 so as to explore the change of serum thyroid hormone levels and its clinical significance.Methods:We selected the 106 clinically diagnosed cases of chronic hepatitis B and 181 cases of hepatitis B patients with cirrhosis as the research object. The chronic hepatitis B patients were divided into mild, moderate and severe groups. Hepatitis B patients with cirrhosis were divided into A, B, C groups according to the Child-Pugh classification.The serum thyroid function was monitored by the Radioimmunoassay. We made the statistical analysis between the severity of the disease and the levels of the thyroid hormone.Results:1.In chronic hepatitis B patients and hepatitis B patients with cirrhosis, the serum FT3,FT4,TT3 and TT4 were significantly reduced and TSH was elevated in Hepatitis B patients with cirrhosis,which was significant difference(t values were 10.17,9.664,9.173,10.676,-3.125, respectively.P<0.01).2.The serum TSH,FT3,FT4,TT3 and TT4 had no statistical significance in chronic hepatitis B light, moderate and severe groups(F values were 1.357,0.646,3.659,0.323,1.987, respectively. P>0.05).3.The serum TSH,FT3,FT4,TT3 and TT4 had statistical significance in Hepatitis B cirrhosis of the liver A, B, C groups(F values were 7.412,16.988,11.795,23.203,19.714,respectively. P<0.01).Further, We used SNK-q test to prove the existence of differences between the two groups.The difference of TSH had no significant difference between A group and B group. The difference of TSH was significant difference between A group and C group,B group and C group.The difference of FT3 had no significant difference between A group and B group. The difference of FT3 was significant difference between A group and C group,B group and C group. The difference of FT4,TT3,TT4 had significant difference between A group and B group,A group and C group,B group and C group.4.The chronic hepatitis B patients and hepatitis B cirrhosis patients of the liver had the normal thyroid function sick syndrome (ESS), usually, performance of low T3 syndrome, low T3, T4 syndrome. The results showed that 10 cases elevated TSH in chronic hepatitis B group, accounting for 9.434 percent of chronic hepatitis B.45 cases increased TSH in hepatitis B cirrhosis, accounting for 24.86% of all patients with liver cirrhosis. TSH levels of the 6 patients with liver cirrhosis in patients with C-level (about 3.315%) significantly increased, reaching Hypothyroidism.Although the proportion of hypothyroidism in Women was higher than males, but no statistical significance.5. FT3, FT4, TT3, TT4 was positively correlated with serum ALB. FT3, FT4, TT3, TT4 was negatively correlated with PT. TSH and serum ALB, PT had no correlation. FT3, FT4, TT3, TT4, TSH had no correlation with TBIL.Conclusions:The serum thyroid hormone levels declines according to the severity of the disease in chronic hepatitis B patients and hepatitis B cirrhosis patients of the liver,which can reflect the liver functional of the reservation.Hepatitis B cirrhosis patients of the liver have the abnormal thyroid function, usually, performance of low T3 syndrome, low T3, T4 syndrome. TSH can be normal, slightly high, and may even reach the hypothyroidism. Serum thyroid hormone levels is positively correlated with serum ALB, a negative correlation with the PT.