Clinical Observation Of Shuangfu Decoction For The Treatment Of Primary Hypertension With Spleen And Kidney Yang Deficiency Syndrome

Objective: To explore the therapeutic effect of Shuangfu Decoction taken at selected time(Silshi and Youshi——the period of the day from 9 am to 11 am,and from 5 pm to 7 pm)combined with irbesartan hydrochlorothiazide tablets on patients with primary hypertension spleen-kidney Yang deficiency syndrome.Methods: 90 patients with grade 2 essential hypertension spleen-kidney Yang deficiency syndrome were randomly divided into three groups(Western medicine control group,traditional Chinese medicine(TCM)timing group and TCM routine group),30 cases in each group.Western medicine control group took irbesartan hydrochlorothiazide tablets(150 mg:12.5 mg)in the morning(7-8 o’clock),1 tablet per day.In the TCM timing group,Shuangfu Decoction was given at Silshi(9-11 o’clock)and Youshi(17-19 o’clock)on the basis of the western medicine control group.In the TCM routine group,Shuangfu Decoction was given in morning and evening(7-8o’clock,19-20 o’clock)on the basis of the western medicine control group.After continuous treatment for 2 weeks,patients’ blood pressure and TCM syndrome score before and after treatment were observed to evaluate the therapeutic effect.Results:1.Blood pressure and TCM syndrome score of the three groups decreased significantly after treatment(P<0.05).The therapeutic effect of Shuangfu Decoction combined with irbesartan hydrochlorothiazide tablets(lowering blood pressure and improving clinical symptoms)was better than that of irbesartan hydrochlorothiazide tablets alone(P<0.05).2.Regardless of blood pressure or TCM syndrome score,the therapeutic effect of TCM timing group was superior to that of TCM routine group(P <0.05).According to theevaluation results of antihypertensive effect,the apparent efficiency of the TCM timing group(73.3%)was higher than that of the western medicine control group(40.0%)and the TCM routine group(60.0%)(P<0.05).The evaluation results of TCM syndrome integration showed that the significant efficiency(76.7%)of the TCM timing group was higher than that of the TCM routine group(63.4%)(P<0.05).Conclusion: In the treatment of essential hypertension,the curative effect of integrated traditional Chinese and Western medicine is better than that of Western medicine alone.Compared with the routine time,taking traditional Chinese medicine at selected time can achieve more synergistic effect.