| Purpose: To evaluate the clinical efficacy of Chinese herbal compound in the treatment of type 2 diabetes mellitus combined with hyperuricemia by meta-analysis.The purpose is to provide more advanced evidence-based medicine for clinical research,to explore its Chinese medicine treatment and prescription rules,to guide clinical practice.Material and method:Using computer to search CNKI,Wanfang Data,CBM,VIPand PubMed.All of the search periods are from January of 2007 to December of 2017,we searched for the key words of "type 2 diabetes mellitus with hyperuricemia","Chinese medicine" and "clinical curative effect".Two researchers independently screened the literature and extracted related information.In case of disagreement,the quality of the included articles was evaluated through discussion or solicitation of third-party opinions,and the relevant data were selected and analyzed by Review Manager 5.3 software.Results:There are 23 articles in total in this study,including 1818 patients with type 2 diabetes mellitus and hyperuricemia,927 in the experimental group and 891 in the control group.Meta-analysis showed that in the total effective rate,The curative effect of traditional Chinese medicine compound alone was better than that of western medicine group(z = 5.12,P <0.00001).The curative effect of traditional Chinese medicine combined with western medicine group was better than Western medicine group,with significant statistical difference of z = 8.05(P <0.00001);Comparing with the control group in reducing blood glucose,blood glucose 2h after meal,serum uric acid,total cholesterol,triglyceride,the result of experimental group was significant.In addition there was not much difference in improving LDL-C between the experimental group and the control group(P> 0.05).Conclusion: 1.Compared with western medicine,Chinese medicine group can significantly improve the total effective rate of type 2 diabetes mellitus combined with hyperuricemia.2.Besides Chinese medicine group is better than Western medicine group in reducing blood sugar,uric acid,total cholesterol,triglyceride and low density lipoprotein cholesterol.There was no significant difference in increasing high density lipoprotein cholesterol(P> 0.05). |
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