Relationship Between Uric Acid And Different Syndrome Types Of Traditional Chinese Medicine In Type Two Diabetes

Objective: To discuss elementarily the relationship between uric acid and different syndrome types of Traditional Chinese Medicine in type 2 diabetes mellitus (T2DM), which provide objective index for differentiation of symptoms and signs in T2DM. Method: 697 patients who were finally diagnosed as T2DM were divided into Yin deficiency and heat excess syndrome, Qi and Yin deficiency syndrome,Yin and Yang deficiency syndrome and syndromes combined with wetness syndrome or with blood stasis syndrome or with both wetness and blood stasis syndromes. The indexes of serum uric acid in each syndrome were tested. Results: There was no statistical significance in age, gender and nation among the Yin deficiency and heat excess syndrome and the Qi and Yin deficiency syndrome and the Yin and Yang deficiency syndrome (P>0.05). As for the uric acid level, the Yin deficiency and heat excess syndrome and Yin and Yang deficiency syndrome were obviously higher than the Qi and Yin deficiency syndrome (P <0.05) and the there was no statistical significance among the Yin deficiency and heat excess syndrome combined with wetness syndrome and with blood stasis syndrome and with both wetness and blood stasis syndromes (P>0.05). The uric acid level of the Qi and Yin deficiency syndrome combined with blood stasis syndrome was higher than that of the Qi and Yin deficiency syndrome and the Qi and Yin deficiency syndrome combined with wetness syndrome and the Qi and Yin deficiency syndrome combined with both wetness and blood stasis syndromes (P <0.05). The uric acid of the Qi and Yin deficiency syndrome combined with both wetness and blood stasis syndromes was higher than that of the Qi and Yin deficiency syndrome combined with wetness syndrome (P<0.05). There was no statistical significance between the Qi and Yin deficiency syndrome and the Qi and Yin deficiency syndrome combined with wetness syndrome (P>0.05). The uric acid level of the Yin and Yang deficiency syndrome was higher than that of the Qi and Yin deficiency syndrome (P<0.05) and that of the Yin and Yang deficiency syndrome combined with wetness syndrome and that of the Yin and Yang deficiency syndrome combined with blood stasis syndrome and that of the Tin and Yang deficiency syndrome combined with both wetness and blood stasis syndromes (P<0.05). There was no statistical significance between the Yin and Yang deficiency syndrome combined with wetness syndrome and the YYDS combined with both wetness and blood stasis syndromes (P>0.05). There were three main groups including the Yin deficiency and heat excess syndrome and the Qi and Yin deficiency syndrome and the YYDS and the uric acid level of each syndrome combined with wetness syndrome was lower than that of other syndromes in each group. Comparied with each wetness syndrome in each group, there was partly statistical significance.The proportion of T2DM with hyperuricemia in the Yin and Yang deficiency syndrome were remarkably more than that in the Yin deficiency and heat excess syndrome and Yin and Yang deficiency syndrome. Conclusions: The cause leading to increase serum uric acid of the Yin deficiency and heat excess syndrome in T2DM could be the high level of uric acid in the simple Yin deficiency and heat excess syndrome and the two facts both wetness and blood stasis couldn't lead to increase the level of uric acid in the group of Yin deficiency and heat excess syndrome. The simple Yin and Yang deficiency syndrome could be the leading cause that increase the level of uric acid in the group of Yin and Yang deficiency syndrome. Blood stasis could be one of the elements leading to increase the level of uric acid in the Qi and Yin deficiency syndrome and Yin and Yang deficiency syndrome groups and wetness could cause lowing uric acid. The high uric acid is mainly in the simple Yin and Yang deficiency syndrome. Wetness and blood stasis could not correlate with the high uric acid in the group of Yin deficiency and heat excess syndrome,but blood stasis could correlate with the high uric acid in both Qi and Yin deficiency syndrome group and Yin and Yang deficiency syndrome group. It suggests that the level of uric acid could be one of the objective indexes for different Traditional Chinese Medicine syndrome types in T2DM and could correlate with the degree of T2DM patient's condition.