Part 1Prevalence and clinical characteristics of fatty pancreas in the examination population in Yangzhou,ChinaBackground and ObjectionThe aim of this study was to investigate the prevalence of and risk factors for fatty pancreas in examination population in Yangzhou,China.MethodsThis was a cross-sectional study.Initially,2093 subjects were included in the study.After the exclusion of 865 subjects based on incomplete information,a total of 1228 subjects were selected for further analysis.The subjects were stratified into two groups(the fatty pancreas group and the non-fatty pancreas group)based on the trans-abdominal US results.The t test and?2 test were used for the preliminary statistical analysis of continuous variables and categorical variables respectively.The body mass index(BMI),abdominal perimeter(AP),blood lipid level,fasting blood glucose(FBG),previous basic medical history(such as fatty liver disease,diabetes,hypertension and MetS)and other parameters were compared between the two groups.A binary logistic regression model was used to identify independent factors associated with fatty pancreas.ResultsAmong the 2093 study subjects,56(2.7%)had fatty pancreas.Overall,53 out of 1228 subjects were diagnosed with fatty pancreas and included into the fatty pancreas group,including 28(52.8%)men and 25(47.2%)women.The remaining population was comprised into non-fatty pancreas group(control group),including 550(46.8%)males and 625(53.2%)females.Univariate analysis showed significant differences in age and the pre-valence of general obesity,central obesity,alcohol consumption,metabolic syndrome and fatty liver between the two groups(all P<0.01),there were no significant differences in blood levels of ?-GGT and SCr?sex,smoking,diabetes and hypertension,(P= 0.081,0.964,0.039,0.062,1.000,0.056,respectively).The fatty pancreas group had higher levels of aspartate aminotransferase,alanine aminotransferase,serum uric acid,fasting blood glucose,total cholesterol,and triglycerides and low-density lipoprotein(LDL)and lower levels of high-density lipoprotein(HDL)than did the non-fatty pancreas group(all P<0.05).Multivariate logistic regression analysis showed that age(P=0.007),central obesity(P=0.002)and fatty liver(P=0.006)were independent risk factors for fatty pancreas,with odds ratios(ORs)of 1.034(95%confidence interval(CI):1.009-1.059),5.364(95%CI:1.890-15.227),and 2.666(95%Cl:1.332-5.338),respectively.ConclusionThe prevalence of fatty pancreas in the examined population is approximately 2.7%.Increased age,central obesity and fatty liver disease are independent risk factors for fatty pancreas.Part 2The Relationship between Hypertriglyceridemic Waist Phenotype and Fatty PancreasBackgroundPrevious studies have shown that hypertriglyceridemic waist phenotype(HTWP)is linked to metabolic diseases and a higher number of cardiovascular risk factors.However,the studies between HTWP and fatty pancreas have not been reported.The primary objective of this study was to investigate the association of HTWP with fatty pancreas.MethodsThis was a cross-sectional study.All 1241 subjects were selected from the Affiliated Hospital of Yangzhou University in China.Elevated waist circumference was defined as>80 cm for women and ?90 cm for men.Elevated triglycerides level(hypertriglyceridemia)was defined as?1.7 mmol/L.All subjects were classified into three phenotypes:normal waist-normal triglyceride group(Group-1),normal waist-elevated triglycerides or elevated waist-normal triglycerides group(Group-2),and elevated waist-elevated triglyceride group(HTWP group,Group-3).All subjects underwent trans-abdominal ultrasonography and were diagnosed with fatty pancreas or fatty liver based on the results.Body mass index,abdominal circumference,blood lipid levels,fasting blood glucose and past medical history were analysed between 3 groups.ResultsA total of 1241 subjects were s elected for further analysis.Compared with the Group-1(n=538)and Group-2(n=424),those in the HTWP group,(Group-3,n=279)had higher total cholesterol,triglycerides,fasting blood glucose,low-density lipoprotein,aspartate aminotransferase,alanine aminotransferase,gamma glutamyl transferase,serum uric acid levels and lower levels of high-density lipoprotein(all P<0.0001).Data analysis also showed significant differences in age,gender,general obesity,central obesity,smoking and drinking between three groups(all P<0.001).Those in the HTWP group had higher prevalence of metabolic syndrome(84.2%),fatty pancreas(10.4%),fatty liver disease(64.5%)and high blood pressure disease(15.8%),all P<0.001.There was no statistical difference in diabetes and SCr levels(P =0.399,0.501).In the fatty pancreas group(n=53),the proportions of HTWP and level of WT index were significantly higher than the non-fatty pancreas group(54.7%vs 23.4%?222±135 vs 142±141),there was significant difference between the two groups(P<0.001).In the ROC curve,when the maximum area under the curve was 0.746,WT index was 107.09,with a corresponding sensitivity and specificity of 90.6%and 51.9%,respectively.ConclusionsHTWP was closely associated with fatty pancreas and can be used as a screening method for fatty pancreas. |