The Study Relationship Between CAS And The Risk Factors Of Patients With Coronary Heart Disease Complicating The Hypertriglyceridemic Waist Phenotype

Objective:To investigate the relationship of abdominal obesity and coronary heart disease (CHD) by analyzing the hypertriglyceridemic waist phenotype, the risk factors of coronary heart disease and the conclusion of coronary angiography.Methods:We collected198CHD patients(male151and female47), aged from thirty two to eighty-five (mean age57.34-10.56years) in the hospital with suspected coronary heart disease during August2010to December2011. All patients'total cholesterol (TC), total triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein—cholesterol (LDL-C), interleukin-6(IL6), hsCRP, fasting plasma glucose(FPG)and blood pressure were detected by the standard methods in3days after hospitalization. Body surveying index consisting of the patients'height, weight and waist circumference Was measured, waist circumferencextriglyceride index(WT index) and body mass index (BMI) were computed. According to the hypertriglyceridemic waist phenotype cut-off point, we enroll whose as abnormal hypertriglyceridemic waist phenotype group (n=126), the others normal hypertriglyceridemic waist phenotype group (n=72). Selected coronary angiography Was completed by special cardiac catheterization doctor to gain various vascular picture of the heart. All patients were calculated the coronary artery score (CAS). Date were pooled to analyze the level of blood lipids, inflammatory markers, FBG, blood pressure in normal hypertriglyceridemic waist phenotype group Versus (VS) hypertriglyceridemic waist phenotype group. Multiple linear correlation and regression analysis were applied to assess the correlationship between WT index, BMI and the aforementioned biochemical indicators, CAS.Results:1,group A of CAS was significantly higher than group B (P<00.1).2, Compared with group B, group A patients with total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),human plasminogen activation inhibitor1(PAI-1),interleukin-6(IL-6),systolic blood pressure (SBP),diastolic blood pressure (DBP), BMI, fasting plasma glucose (FPG),free fatty acid (FFA) fibrinogen (Fib),tumor necrosis factor-alpha (TNF-a) and high-sensitivity C-reactive protein (hsCRP) levels were significantly higher (P<0.05); adiponectin (APN),high density lipoprotein cholesterol (HDL-C) levels were significantly lower (P <0.01).3,CAS of all selected patients with CHD and multiple linear regression correlation analysis of the risk factors:WTindex,hsCRP,PAI-1and TC was significantly positively correlated with the CAS; HDL-C, APN was significantly negatively correlated.4,WTindex with FFA,SBP was significantly positively related.Conclusion:1,Combined high triglycerides waist phenotype (HTWP) in patients with CHD risk factors levels (such as the CAS, the TC, LDL-C, PAI-1, IL-6, the SBP, DBP, and BMI, and of FPG, Fib, TNF-alpha, hsCRP and FFA etc.) were significantly higher than normal triglyceride waist phenotype in patients with CHD, while the former severe coronary lesions than the latter.2,Comprehensive report of abdominal obesity and elevated TG new index WTindex and the severity of coronary lesions and CHD traditional risk factors are closely related, so WTindex may be judged CHD risk is a useful indicator, also may be CHD populations at risk for early intervention targets.