Comparison Of The Efficacy Of Nalbuphine And Dizocine In Intravenous Controlled Analgesia After Laparoscopic Gastrointestinal Surgery

Objective:Analysis and comparison of the efficacy of nabulphine and dizocine combined with sufentanitril(PCIA)in laparoscopic radical resection of gastric cancer and colorectal cancer.To provide help for postoperative quality of life of patients with this type of surgery.Methods:In this study,140 patients who underwent elective laparoscopic radical surgery for gastric cancer and colorectal cancer in the second affiliated hospital of nanchang university from April 2019 to February 2020 and voluntarily signed up for postoperative use of PCIA were selected.The patients were selected according to their age:25-75 years old,body mass index(BMI)18-30kg/m~2,and ASA grade I~III.All patients were treated with only intravenous controlled analgesia as the analgesia program.Two groups were randomly divided into N group and D group.The drugs in the analgesic pump were sufentanil 1.0ug/kg+nalbuphine 1mg/kg+toranisetron 5mg,which was diluted to 120ml in normal saline;sufentanil 1.0ug/kg+dizoxine 0.4mg/kg+toranisetron 5mg,which was diluted to 120ml in normal saline in group D.Setting parameters of analgesic pump:no load dose,continuous dosage:2.5ml/h,automatic dosage:2ml/h,locking time:15 minutes.Then collect the data needed to observe the experiment.We mainly observed and analyzed the Visual Analogue Scale(VAS)scores of patients in the two groups at 6h,12h,24h and 48h after surgery and Visual Analogue Scale(VAS)scores of patients after exercise at 6h,12h,24h and 48h.The patient had dizziness,nausea,vomiting,itchy skin and other adverse reactions after the operation.Postoperative use of remedial analgesics and antiemetic drugs;Record the total times of additional pressure on the analgesic pump after operation.Postoperative anal exhaust time was recorded,the first time out of bed activity;Postoperative analgesia satisfaction score of patients.Results:The number of postoperative analgesic pump compressions in group N was significantly lower than that in group D(P<0.05).The incidence of adverse reactions such as dizziness,nausea and vomiting in group N was significantly lower than that in group D(P<0.05).The use of remedial analgesics and antiemetics in group N was significantly lower than that in group D(P<0.05).The satisfaction of postoperative analgesia in group N was significantly higher than that in group D(P<0.05).VAS scores in N group were lower than that in D group at 6h,12h,24h after the operation(P<0.05),and there was no significant difference in VAS scores in N group at 48h after the operation(P>0.05).Due to the intervention of the surgeon,there was no significant difference in postoperative anal exhaust time and postoperative out-of-bed activity time between the two groups(P>0.05).Conclusion:Compared with dezocine,nabphine can effectively reduce postoperative pain in patients undergoing laparoscopic major abdominal surgery,reduce VAS pain score within 24 hours after surgery,and reduce the incidence of postoperative adverse reactions such as nausea and vomiting.Patients have a higher satisfaction score for postoperative analgesia effect.