Correlation Analysis Of Serum TBIL,GGT And Large Artery Atherosclerotic Stroke

Objective:To explore the correlation between serum total bilirubin(TBIL),gamma glutamyl transferase(GGT)and the incidence of large artery atherosclerotic(LAA)stroke and the degree of neurological deficit(NIHSS scores)so as to provide new ideas for the prevention and treatment of large artery atherosclerotic stroke.Methods:A total of 98 patients with large artery atherosclerotic stroke admitted in the Neurology Department of our hospital from January 2018 to December 2019 were selected as the case group to collect age,gender,smoking history,hypertension history,diabetes history,heart disease history,triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL),uric acid(UA),creatinine(Cr),total bilirubin(TBIL),gamma glutamyl transferase(GGT),carotid intima media thickness(IMT),and NIHSS scores.In the same period of time,98 healthy subjects in the physical examination center of our hospital were selected as the control group,and relevant data were collected.All data were analyzed and processed by SPSS 22.0 statistical software.Results:1.There was no statistical significance in age,sex,history of heart disease,UA,Cr,and TG between the two groups(p>0.05).Serum TBIL levels were lower in cases than in controls,but smoking history,hypertension history,diabetes history,IMT,LDL,TC,and GGT were higher in cases than in controls,with statistical significance(p<0.05).2.All subjects were divided into four groups according to quartiles of serum TBIL levels,which were TBIL≤12.7(n=50),12.7~14.2(n=48),14.2~15.1(n=49),and TBIL>15.1(n=49).The stroke risk of 14.2-15.1 subgroup and TBIL>15.1 subgroup was lower than that in TBIL≤12.7 subgroup.The OR values were 0.391 and 0.264,respectively,with statistical significance(p<0.05).The stroke risk of 12.7~14.2subgroup was lower than that in TBIL≤12.7 subgroup,with no statistical significance(p=0.059).3.All subjects were divided into four groups according to quartiles of serum GGT levels,which were GGT≤27.5(n=49),27.5~34.5(n=49),34.5~41.8(n=49),and GGT>41.8(n=49).Use GGT≤27.5 subgroup as reference,the OR values were 2.293,2.438,and 4.160,respectively.And the stoke risk of GGT>41.8 subgroup was 4.160times higher than that in GGT≤27.5 subgroup(p=0.003).4.The TBIL levels were negatively correlated with NIHSS scores in patients with large artery atherosclerotic stroke.Spearman correlation coefficient was r_s=-0.694,with statistical significance(p<0.001).The patients were divided into four groups according to quartiles of serum TBIL levels.The results showed that the NIHSS scores of the four groups were statistical significance(H=49.046,p<0.001).5.The GGT levels were positively correlated with NIHSS scores in patients with large artery atherosclerotic stroke.Spearman correlation coefficient was r_s=0.516,with statistical significance(p<0.001).The patients were divided into four groups according to quartiles of serum GGT levels.The results showed that the NIHSS scores of the four groups were statistical significance(H=26.952,p<0.001).6.There was a negative correlation between serum TBIL and GGT in patients with large artery atherosclerotic stroke,and the correlation coefficient was r=-0.308,with statistical significance(p=0.002).Conclusions:1.Serum GGT may be a risk factor for large artery atherosclerotic stroke and is related to the degree of neurological deficit.2.Appropriate high levels of serum TBIL may reduce the risk of large artery atherosclerotic stroke and have a protective effect on it.3.There was a negative correlation between serum TBIL and GGT in patients with large artery atherosclerotic stroke.