| Background Parkinson’s disease(PD)is a progressive neurodegenerative disease,which is the third leading cause of death in the elderly.In recent years,an increasing number of studies have found that non-motor symptoms in PD especially pain seriously affect patients’ the quality of life,to which clinicians should pay more attention and then give reasonable treatment to relieve the psychological pressure of these patients and their families.Foreign studies have found that the prevalence of pain in Vascular Parkinsonism(Vascular Parkinsonism,VaP)is second only to that of PD.However,there are currently no related studies on the difference of pain prevalence,characteristics,and drug response between patients with PD and VaP.Objective To perform a comparative analysis of the relationships of pain with dyskinesia and quality of life in PD and VaP patients.Methods Participants receiving outpatient or inpatient treatment were recruited from Anhui Provincial Hospital Affiliated to Anhui Medical University were enrolled from January 2017 to January 2019,including 65 with PD and 65 with VaP.General data were collected.The King’s Parkinson’s disease Pain Scale(KPPS),UPDRS-Ⅲ(Motor Examinationpart 3 of the Unified Parkinson’s Disease Rating Scale),Hospital Anxiety and Depression Scale(HADS),and 39-item Parkinson’s Disease Questionnaire(PDQ-39)were used to measure the items of pain,level of dyskinesia,prevalence of anxiety and depression,and quality of life,respectively,in all patients.Hoehn and Yahr(HY)Scale was used to assess the stage of PD.The differences in pain prevalence,single-site pain score,location,and treatment were collected to be compared in PD and VaP groups.Finally,according to whether or not with pain,the PD group and VaP group were namely divided into two groups.We analyzed the relationship of pain with disease course,dyskinesia,BMI,comorbidities,anxiety and depression and quality of life.Results Compared with PD patients,VaP patients had greater mean age and BMI,higher prevalence of hypertension and diabetes,higher mean UPDRS-Ⅲ score,but shorter mean duration of disease,lower mean KPPS score and lower incidence of pain(P<0.05).Compared with PD patients with pain,VaP patients with pain had greater mean age,lower mean duration of disease,and lower prevalence of pain occurring in the shoulder,back and neck.Pain occured more frequently in shoulder,back and lumbar in PD while lower limbs and lumbar in VaP.The motor symptoms were relieved by dopaminergic drugs(mainly levodopa)in all PD patients with pain,but only in 72.4%(n=21)of VaP patients with pain.Compared with PD patients without pain,PD patients with pain had higher mean disease severity level,UPDRS-Ⅲ score,anxiety score,depression score,and PDQ-39 score(P< 0.05).VaP patients with pain had lower mean BMI and higher mean PDQ-39 score than those without(P<0.05).Conclusions Patients with PD and VaP both are prone to pain.The more severe the motor symptoms and emotional disorders are,the more likely they will suffer from pain and the worse quality of life they will have.Clinicians should strengthen their understanding of pain in these diseases and standardize the pain management to improve patients’ quality of life. |
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