Correlation Between Carotid Plaque Properties And Serum Uric Acid And Its Relationship With The Severity Of Coronary Artery Disease In Patients With Coronary Heart Disease

Objective:The subjects of this study were patients with coronary heart disease diagnosed by coronary angiography,and the risk factors affecting the properties of carotid plaque were studied.the main research contents are hematological indexes,including blood lipid level,fasting blood glucose,serum uric acid,homocysteine and so on.at the same time,the correlation between the properties of carotid plaque and risk factors was evaluated,so as to analyze the effect of hematological indexes on the properties of carotid plaque in patients with coronary heart disease complicated with carotid plaque.This study also collected the results of coronary angiography in patients with coronary heart disease,including the coronary artery Gensini integral,the lesions mumber of coronary artery,and analyzed the relationship between the properties of carotid plaque and the severity of coronary artery disease.It is expected that the results of the study can help guide the clinical work.Methods:Choicing the patients with suspected coronary artery disease from the Department of Cardiology or Department of Geriatrics(Cardiology Group)in The First Hospital of Shanxi Medical University from March 2018 to April 2019,whom confirmed by coronary angiography and further detected by carotid artery color Doppler ultrasound(Philips IU22/IE33)to investigate the cervical vascular plaque.According to the results,127patients were enrolled as the study subjects,including 78 patients in the unstable plaque group,49 patients in the stable plaque group.Gathering the general information,blood index,the coronary artery Gensini integral and the lesions mumber of coronary artery and put them for statistically analyzed.The counting data are expressed as examples(percentages),and the comparison of inter-group rates is carried out by means of the χ2test.The measurement data were expressed as x±s,and the mean between the two groups was tested by t-test.Results:In 127 patients,the levels of serum uric acid and homocysteine in unstable carotid plaque group were significantly higher than those in stable plaque group(P<0.05).Binary Logistic regression analysis of carotid plaque properties showed that serum uric acid was associated with plaque instability(OR=1.020,P<0.05),indicating that high serum uric acid levels increased the risk of unstable plaque in patients with coronary heart disease(CHD).In the analysis and study of the properties of carotid plaque and the severity of coronary artery disease,it was found that the coronary artery Gensini integral and the lesions mumber of coronary artery in unstable carotid plaque group were higher than those in stable plaque group(P<0.05),which indicated that patients with unstable carotid plaque were more likely to have severe coronary artery disease.Conclusion:The increase of serum uric acid level in patients with coronary heart disease is closely related to the instability of carotid plaque.The instability of carotid plaque can be used as an index to predict and evaluate the severity of coronary artery disease in patients with coronary heart disease.