Application Of Three-dimensional Arterial Spin Labeling Technique In Intravenous Thrombolytic Therapy For Acute Cerebral Infarction

Objective: To study the value of three-dimensional arterial spin labeling(3D-arterial spin labeling,3D-ASL)in intravenous thrombolysis for acute cerebral infarction.Methods: Collected 50 patients with acute cerebral infarction who were hospitalized in the Department of Neurology of our hospital,from November 2018 to December 2019,and received rt-PA intravenous thrombolysis as the experimental group,and 50 patients with acute cerebral infarction who did not receive thrombolysis as the control group during the same period.The clinical data of the experimental group and the control group were collected,including sex,age,hypertension,diabetes,hyperlipidemia,atrial fibrillation,high homocysteine,smoking,drinking,NIHSS score in different time periods and m RS score on the 7th day after admission.The imaging data included cerebral blood flow in the lesion area,cerebral blood flow in the mirror area,DWI infarct area,ASL ischemic area and the degree of MRA stenosis.Respectively take the corresponding statistical analysis of the above different data to draw a conclusion.Results:(1)There was a statistical difference between the CBF value of lesion area(35.44±11.21)in the experimental group and the CBF value of lesion area(26.55±10.21)in the control group(t=4.148,Pt=0.05).(2)The ΔNIHSS scores of experimental group(3.32±2.94)and control group(0.18±0.44)were statistically different(t=7.745,P<0.05).The CBF value of the lesion area of the patients with obvious thrombolytic effect was statistically different from that of the patients with no obvious effect(P<0.05),and the score of 7 days m RS the experimental group and the control group was negatively correlated with the cerebral blood flow in the lesion area(the experimental group r=-0.3931,the control group r=-0.5864).(3)Among the patients with large area infarction,small area infarction and lacunar infarction in the experimental group,the probability of low perfusion was 80.0%,40.0% and 10.0%.Among the patients with large area infarction,small area infarction and lacunar infarction in the control group,the probability of low perfusion in 3D-ASL was 96.6%,66.7% and 33.3%.(4)The MRA showed that there was significant difference between the CBF values of the lesion area corresponding to the degree of stenosis of different grades of the responsible,and the difference was statistically significant(P<0.05).Conclusion:(1)rt-PA intravenous thrombolytic therapy can increase cerebral blood flow and decrease hypoperfusion area.(2)rt-PA intravenous thrombolysis can improve the early NIHSS score of patients more effectively,and the faster the recovery of cerebral blood flow in the lesion area NIHSS the better the score is.patients with relatively high cerebral blood flow in the lesion area had better early prognosis.(3)Different detection rates of hypoperfusion between patients with intravenous thrombolysis and patients without thrombolysis by 3D-ASL technique;degree of vascular stenosis affects cerebral blood flow perfusion.