| Objective:The limited bowel preparation protocol of Mongolian medicine Amuri-6 and bisacodyl combined with iodine-barium labeling method was applied to the preparation process of CT colonography.The effective labeling of colorectal residual contents by this method and the application value of Mongolian medicine Amuri-6 in clinical CT colonography examination was studied.And compare it with bisacodyl to analyze the feasibility of the more economical Mongolian medicine Amuri-6 instead of bisacodyl for CT colonography.Methods:From August 2016 to November 2019,a total of 51 patients with clinical diagnosis of colorectal disease or a high incidence of colorectal disease were recruited to participate in this study.They were instructed to randomly receive Mongolian medicine Amuri-6 or bisacodyl in limited bowel preparation protocol with iodine-barium labeling method before CT colonography examination,including a low residue diet,oral Mongolian medicine Amuri-6 or bisacodyl as a stool softener,oral barium sulfate suspension and iohexol for labeling colorectal residues.The Mongolian medicine Amuri-6 group and the bisacodyl group contained 26 and 25 subjects,respectively.According to the results of questionnaire feedback,the side effects(abdominal pain,bloating,etc.)degree,diarrhea degree and subjective acceptance degree of Mongolian medicine Amuri-6 or bisacodyl bowel preparation were statistically analyzed,and the patient’s tolerance difference between the two preparation protocols was comprehensively compared.Colorectal distention was performed on the day of the examination,and the images were obtained by 64-row single-source Discovery CT.The obtained CT images were analyzed,and the cleanliness of the colorectal residual liquid and stool of Mongolian medicine Amuri-6 and bisacodyl was compared.Evaluate the effective labeling of residual colorectal contents after labeling with the iodine-barium method and explore the difference between the impact of the two drugs on the contrast method based on the difference in labeling effect and CT value of the residual liquid.The quality and difference of the images obtained from the Mongolian medicine Amuri-6 group and the bisacodyl group were comprehensively evaluated by the amount of residual colorectal contents,the degree of colorectal distention,image artifacts and clarity.Results: 1.26(100%)patients within the Mongolian medicine Amuri-6 group and 25(100%)patients within the bisacodyl group were able to tolerate the limited bowel preparation protocol combined with the Amuri-6 and bisacodyl respectively.And the difference in the degree of side effects(such as abdominal pain,bloating,etc.),the degree of diarrhea,and the degree of subjective acceptance during the preparation process were not statistically significant(P > 0.05).Compared with the bisacodyl group,the Mongolian medicine Amuri-6 group had a higher degree of cleanliness of colorectal residual fluid(P < 0.05),but there was no significant difference in the degree of cleanliness of colorectal residual stool(P > 0.05).2.After 51 patients were labeled with the iodine-barium labeling method,the effective labeling of total colorectal contents could reach 84.62%,of which 81.20% of the residual contents was 100% labeled.After the Mongolian medicine Amuri-6 group and bisacodyl group were labeled by this method,the effective labeling of colorectal contents in their patients were 82.65% and 86.72%,respectively,and the difference between the two groups was not significant(P > 0.05).In addition,the CT value of the colorectal residual fluid of the Mongolian medicine Amuri-6 group was higher than that of the bisacodyl group(P < 0.05).3.The Mongolian medicine Amuri-6 group and bisacodyl group had the images of 81.54% colorectal segments and 84.80% colorectal segments respectively,which quality met the diagnostic requirements and was acceptable in the clinic.And the degree of colorectal distention of the ascending colon in the two groups was better than that of the descending colon,and the difference was statistically significant(P < 0.05).In the Mongolian medicine Amuri-6 group,the images of 85.38% colorectal segments has a small amount or less of artifacts,and the tissue structure is good to meet the diagnostic requirements,while 92.00% colorectal segment images in the bisacodyl group can meet the requirements,but the differences in image artifacts and clarity between the two groups were not statistically significant(P > 0.05).Conclusion : The limited bowel preparation protocol of Mongolian medicine Amuri-6 combined with iodine-barium labeling method has the feasibility of CT colonography.Compared with bisacodyl,Amuri-6,a Mongolian medicine,has no significant effect on the tolerance of patients in the preparation process.The labeling of colorectal contents by the iodine-barium method can obtain a satisfactory labeling effect.CT colonography using the two drugs combined with iodine-barium labeling method can obtain good scanning images.At the same time,the Mongolian medicine Amuri-6 has better economic benefits,so it is preliminarily considered that it can be used as an alternative medicine for bisacodyl in the bowel preparation process before CT colonography. |
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