The Correlation Between Primary Breast Cancer And Secondary Primary Cancer:a Meta-analysis

Objective To examine the correlation between primary breast cancer and secondary primary cancer in women diagnosed with a first primary breast cancer.Methods The Literature searched online databases including Pub Med,Embase,the Cochrane Library,CNKI,VIP and Wan Fang Data,including studies published up from June 2019.The Newcastle-Ottawa Scale(NOS)was used for literature quality evaluation.Rev Man5.3 software was used to analyze the data.Results A total of 13 studies were included with differences in inclusion and exclusion criteria,the definition of multiple primary cancers,and the second cancer sites included.The results of the Meta-analysis of the included studies showed that primary breast cancer patients had a 14% increased risk of secondary primary cancer compared to the general population(RR = 1.14,95%CI: 1.05-1.23).By region groups,the difference between the European group(RR = 1.16;95% CI: 1.07-1.26)and the Asian group(RR = 1.13;95%CI: 1.01-1.27)in RR was not significant.By age groups,RR estimates were 1.49(95%CI: 1.37-1.62)of premenopausal breast cancer patients(≤50 years old)and 1.15(95%CI: 1.07-1.23)of postmenopausal breast cancer patients(>50 years old).Conclusions Women diagnosed with primary breast cancer for the first time have a higher risk of developing a second primary cancer than the general population.