Comparison Of Pregnancy Outcomes Of Frozen Embryo Transfer In ICSI/PGT-ART

Objective:To compare the pregnancy outcomes of ICSI/PGT blastocyst cryopreservation cycle in order to guide the clinical application of PGTMethods:A total of 322 patients in the PGT group and 730 patients in the ICSI blastocyst group were collected from January 2016 to December 2018 in the frozen embryo transfer cycle in our center.The clinical pregnancy rate,miscarriage rate,and neonatal weight were compared between the two groups.Indicators such as the length of the newborn,premature birth rate,live birth rate,fetal malformation rate and the incidence of pregnancy complicationsResults:Except for the type of infertility,the basic clinical indicators of the two groups have no significant difference(P>0.05).The clinical pregnancy rate in the PGT group was 71.4%,and the clinical pregnancy rate in the ICSI blastocyst group was 62.6%The difference between the two groups was statistically significant(P=0.006);the abortion rate was 11.3%in the PGT group and 19.9%in the ICSI blastocyst group,the difference between the two groups is statistically significant(P=0.005).The live birth rate was 63.4%in the PGT group and 50.1%in the ICSI blastocyst group.The live birth rate in the PGT group was significantly higher than that in the ICSI blastocyst group(P<0.05),with a significant difference.There were no stillbirths in both groups.Other analysis indicators such as premature birth rate(7.6%in the PGT group and 7.7%in the ICSI blastocyst group),neonatal body weight(3431.1 ±40.1g in the PGT group,3359.4± 51.6g in the ICSI blastocyst group),and length of the newborn(in the PGT group)50.6±2.7cm,ICSI blastocyst group 49.5±7.4cm),there was no statistical significance(P>0.05).One case of fetal malformation in the ICSI blastocyst group was congenital heart disease.A total of 204 live births were obtained in the PGT group,including 12 cases of gestational diabetes,17 cases of gestational hypertension,and 7 cases of premature rupture of membranes.A total of 366 live births were obtained in the ICSI blastocyst group,including 25 cases of gestational diabetes,35 cases of gestational hypertension,and 21 cases of premature rupture of membranes.The difference between the two groups was not statistically significant.After age stratification,the live birth rate and pregnancy rate in the PGT group were higher than the ICSI blastocyst group(P>0.05),and the miscarriage rate was lower than the ICSI blastocyst group(P>0.05)There was no statistical difference Significantly,but the difference in pregnancy rate,live birth rate,and miscarriage rate is more obvious than that in the groups<30 years old and 30-40 years oldConclusion:PGT can reduce miscarriage rate and increase clinical pregnancy rate and live birth rate.PGT is a safe and reliable technology.Older women may benefit from PGT.