Correlation Between Serum Total Bile Acid Levels And Cardiac Function In Patients With Chronic Heart Failure Complicated With Diabetes Mellitus

Objective: To investigate the correlation between serum total bile acid levels and cardiac function indexes in patients with chronic heart failure combined with diabetes mellitus.Methods: From September 2017 to September 2019,139 patients with chronic heart failure(CHF)who were hospitalized in the The Fourth Affiliated Hospital of China Medical University were selected,and 19 healthy people who had received physical examination at our hospital during the same period were selected as a control group,serum total bile acid(TBA)and BNP levels were measured in all subjects.Echocardiography was performed to measure the left ventricular ejection fraction(LVEF)and left ventricular end diastolic diameter(LVEDd).Divided into 78 patients in CHF-DM group and 61 in simple CHF group according to whether they had diabetes mellitus(DM),and compared serum TBA levels in each group;correlation analysis of serum TBA and NYHA cardiac function classification,BNP,LVEF,and LVEDd in CHF-DM patients;Record the event of cardiac function decline in the CHF-DM group during hospitalization,and perform binary logistic multivariate analysis on the occurrence of this event;ROC curve to evaluate the predictive value.Results:1.The serum TBA of the CHF-DM group and the simple CHF group was higher than that of the control group,and the serum TBA level of the CHF-DM group was the highest,the difference was statistically significant(P<0.05).2.In the CHF-DM group,the serum TBA level increased with the increase of cardiac function grade,which was statistically significant(P<0.05).3.In the CHF-DM group,serum TBA was positively correlated with BNP and LVEDd(r=0.467,0.36,both P<0.01),negatively correlated with LVEF(r=-0.471,P<0.01),with statistical significance.4.Serum TBA,BNP,and age are the risk factors for cardiac function decline in CHF-DM patients during hospitalization.Serum TBA has a predictive effect on cardiac function decline.Conclusion: Serum total bile acid levels can be used as an index for evaluating cardiac function in patients with chronic heart failure and diabetes mellitus,and provide a new reference for clinical guidance and prognosis.