Analysis Of Blood Group And Urinary Tract Infection In Patients With Bladder Cancer

Objective: 1.A retrospective study was performed between the bladder cancer group and the control group to find out whether the ABO blood group was associated with the risk of bladder cancer.2.The analysis of postoperative urinary tract infection in patients with bladder cancer was performed to help the treatment of such patients.Methods: 1.The 707 bladder patients and 797 healthy blood donors were selected as subjects,and univariate and multivariate logistic regression analysis were performed to investigate the relationship between ABO blood type and the risk of bladder cancer.2.We compared the postoperative urinary tract infections between patients with bladder cancer and urethral calculi and compared the distribution and the resistance rate of pathogens between the two groups.Results: 1.The blood group distributions of the bladder cancer group and the control group were: the bladder cancer group B> A> O> AB,the control group A> B> O> AB.Univariate analysis showed that the sex ratio(male/female)in the bladder cancer group was significantly higher than that in the control group,and there was a significant difference in age distribution between the two groups.After adjusting for age and gender,compared with patients with type O blood,patients with blood type A(AOR= 1.701;95%CI: 0.983-2.941,P= 0.058)and patients with blood type AB(AOR= 1.583;95%CI:0.721-3.479,P= 0.253)and patients with blood type B(AOR= 1.593;95% CI:0.902-2.812,P= 0.108)did not significantly increase the risk of bladder cancer,patients with non-O blood type(A,B,and AB)had an AOR of 1.623(95% CI: 1.005-2.622,P=0.048)and increased the risk of bladder cancer.We further evaluated whether smoking,diabetes mellitus and hypertension impacted the link between ABO blood type and the risk of UC: smoking did not affect the relationship between bladder cancer risk and ABO blood type;among patients with hypertension,patients with blood type AB showed a higher risk of bladder cancer than patients with blood type O(AOR= 0.533;95% CI:0.310-0.914,P = 0.022).In addition,among patients with diabetes,patients with blood type AB showed a higher risk of bladder cancer than patients with blood type O(AOR=0.424;95% CI: 0.211-0.854,P= 0.016).We analyzed and evaluated the relationshipbetween the clinicopathological factors and the ABO blood type in patients with bladder cancer: ABO blood group of bladder patients had no significant correlation with tumor stage(O and non-O: AOR= 1.039,95% CI: 0.747-1.446,P= 0.820;O and A: AOR=0.979,95% CI: 0.660-1.452,P= 0.916;O and B: AOR=0.914,95% CI: 0.528-1.582,P=0.747;O and AB: AOR= 1.136,95% CI: 0.776-1.662,P= 0.512).At the same time,there was no significant difference between tumor grade and ABO blood type in bladder patients(O and non-O: AOR = 1.254,95% CI: 0.902-1.744,P= 0.179;O and A: AOR =1.299,95% CI: 0.8571-1.929,P= 0.194;O and B: AOR= 1.119,95% CI: 0.766-1.634,P= 0.562;O and AB: AOR= 1.650,95% CI: 0.957-2.843,P= 0.071).2.The comparisons of patients with bladder cancer and patients with urethral calculi were: the postoperative urinary tract infection rate was 23.37% in the bladder cancer group and 9.23% in the control group.The incidence of urinary tract infection was significantly different between the bladder cancer group and the control group(P=0.001).The compositions of pathogenic bacteria of the two groups were mainly Gram-negative bacteria,followed by Gram-positive bacteria.The Enterobacteriaceae were accounted for most of the negative bacteria,and the positive bacteria were mainly composed of Enterococcus.There was no significant difference in the distribution of pathogenic bacteria.There was no significant difference in the drug resistance rates of the Enterobacter bacteria listed in the group.The drug resistance rates of amikacin,cefepime,piperacillin / tazobactam,cefoperazone /sulbactam,imipenem,meropenem,and furantoin were all <30%.There was no difference in drug resistance rates between the two groups of Enterococcus.The drug resistance rates of teicoplanin,vancomycin,and linezolid were all 0.Other drugs were basically>30%.Conclusion: 1.The risk of bladder cancer is related to the ABO blood type,and the patients of non-O blood type have an increased risk of bladder cancer;AB patients with hypertension or diabetes have an increased risk of bladder cancer;the tumor stage and the tumor grade of bladder cancer are not related to the ABO blood type.2.Urinary tract infections are prone to occur in patients with bladder cancer after surgery.The main pathogens isolated include Enterobacteriaceae from Gram-negative bacteria and Enterococcus from Gram-positive bacteria.Cefoperazone / sulbactam and piperacillin /tazobactam are preferred for urinary tract infections caused by Enterobacteriaceae,carbapenems can be used for urinary tract infections caused by severely complicated Enterobacteriaceae;vancomycin,linezolid,and teicoplanin are most effective in treating urinary tract infections caused by Enterococci.