Correlation Between Monocyte/High Density Lipoprotein Ratio And Lower Extremity Atherosclerosis Disease In Patients With Type 2 Diabetes Mellitus

Objective: To investigate the relationship between monocyte / high density lipoprotein ratio and lower extremity atherosclerosis disease in patients with type 2 diabetes mellitus.Methods: Four hundred patients with type 2 diabetes mellitus were selected and divided into four groups according to the severity of atherosclerosis,Including: T2 DM + AS1 group(n=109,simple T2 DM patients),T2 DM + AS2 group(n=97,T2 DM with intimal thickening of lower limb arteries),T2 DM + AS3 group(n=109,T2 DM with arterial plaque formation of lower extremity),T2 DM + AS4 group(n=85,T2 DM with stenosis of lower extremity artery).Collect general clinical data of 4 groups of patients and calculate MHR values based on peripheral blood test results,The correlation between MHR and lower extremity atherosclerosis was statistically analyzed using SPSS25.0 software.Results: 1.The age,course of type 2 diabetes,gender,smoking history,drinking history,hypertension history,insulin application history,MHR,BMI,monocyte,lymphocyte,FPG,HDL-C,Hb A1 c and Cr of the four groups were all statistically significant(P < 0.05).2.Spearman correlation analysis showed that in T2 DM patients,MHR was positively correlated with BMI,neutrophil,monocyte,lymphocyte,TG,UA and Cr(P < 0.05).3.Two-class logistic regression analysis showed that MHR(OR = 2.101,95% CI 1.362~3.242;P = 0.001),age,history of hypertension,and smoking history were risk factors for lower extremity AS in T2 DM patients.BMI and lymphocyte were protective factors of lower extremity AS in T2 DM patients.4.Multi-class logistic regression analysis showed that age and smoking history were risk factors affecting AS2-AS4 grade of lower extremities in T2 DM patients,MHR(AS3 OR = 2.498,P = 0.000;AS4 OR = 2.905,P = 0.000)and history of hypertension are risk factors that affect the occurrence of AS3 and AS4 in lower extremities in patients with T2 DM,The course of disease is a risk factor affecting AS4 grade of lower limbs in T2 DM patients,and BMI is a protective factor affecting AS2-AS4 grade of lower limbs in T2 DM patients.Conclusion: MHR is closely related to LEAD and the severity of LEAD in T2 DM patients.With the increase of MHR,the severity of as in the lower extremity of T2 DM patients increased gradually,mainly in AS3 and AS4 patients.