| Objective:Most patients with schizophrenia will have different degrees of cognitive impairment,mainly reflected in memory,attention,reasoning and problem processing ability,information integration and processing speed,social cognitive ability and other aspects.Cognitive impairment is also an important core symptom of schizophrenia and can be an extremely important indicator of disease prognosis.In this study,the cognitive function of some schizophrenics in Shenyang mental health center was evaluated to explore the relevant factors affecting the cognitive function of schizophrenics and the relationship between the cognitive function and clinical symptoms of schizophrenics.It is helpful to improve the cognition,diagnosis and treatment of the cognitive function of patients with schizophrenia,and to provide some reference for the prevention and treatment of schizophrenia and its prognosis.Methods: In this study,305 patients with schizophrenia who met the inclusion and exclusion criteria were selected from August 2018 to October 2019.Investigate the general situation of all patients(sociodemographic information and clinical history of patients),and use the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)to assess patients’ cognitive function and concise mental illness.The Brief Psychiatric Rating Scale(BPRS)measures the severity of psychiatric symptoms in patients.All the data collected above were recorded in the form of Excel sheets.SPSS21.0 software was used for statistical analysis.Analysis of influential factors of cognitive function in patients with schizophrenia was performed by analysis of variance or t test.Multivariate analysis using multiple linear stepwise regression analysis.Correlation analysis was performed by Pearson correlation analysis.Results: 1.Among the 305 patients with schizophrenia,the majority were women(60.66%);mainly those over 30 years of age(87.21%);slightly higher numbers were in high school or technical secondary school(47.87%);occupations were workers(28.52%),and unemployed(29.51)%)More people;mainly urban population(68.20%),no family history(64.92%)paranoid type is the most(65.24%);mostly relapsed(61.31%);≤ 5years in the course of disease(44.26 %),6-10 years(49.18%);the length ofhospitalization was 4-6 months(41.97%);olanzapine was the most used(40.00%).2.The total RBANS and BPRS scores of 305 patients were 50-89 points(65.68±6.23 points)and 35-57 points(47.79 ± 3.45 points).3.Single factor analysis showed that gender,age,marriage,education,occupation,living area,diagnostic typing,incidence,duration,length of hospital stay,and medication were all influencing factors for cognitive impairment in patients with schizophrenia.4.The results of multivariate analysis showed that age,marriage,education level,living area,morbidity and course of disease were included in the multiple linear regression model,and the influence of age(B=1.01)and morbidity(B=1.01)on cognitive function was the most significant.5.Pearson correlation analysis of the relationship between cognitive function and mental symptoms showed that the speech function score in RBANS was negatively correlated with anxiety and depression factors in BPRS(r=﹣0.315,P<0.05),and the visual breadth and attention score in RBANS were negatively correlated with the lack of vitality factor in BPRS(r =﹣0.251,﹣0.208,P<0.05).There was no significant correlation between the scores of other cognitive dimensions assessed by RBANS and the factors assessed by BPRS(P >0.05).Conclusion: The cognitive function of patients with schizophrenia is affected by many factors,among which age and first and recurrence have the most significant effects on cognitive function.Part of the cognitive function of patients with schizophrenia is related to negative symptoms,and there is no significant correlation with positive symptoms.In clinical practice,it is suggested to pay attention to the negative symptoms of patients,which has certain reference significance for psychiatrists to recognize the relevant factors of cognitive function of patients with schizophrenia. |
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