| Objective:By analyzing and sorting out the clinical data of patients with polycystic ovary syndrome(PCOS),this study explored the differences between family history of diabetes,clinical characteristics and biochemical levels of PCOS patients with phlegm-dampness syndrome and non-phlegm-dampness syndrome,so as to provide a basis for determining the clinical treatment plan and observing the efficacy.Methods:From September 2017 to January 2020 into the first affiliated hospital of heilongjiang university of TCM gynecology outpatient clinical screening qualified in information integration system of scientific research in cases of PCOS,a total of 1007 cases,according to the presence of a strong family history of diabetes and phlegm dampness syndromes or not is divided into four groups,and have a family history of diabetes are phlegm dampness syndromes group(n = 234),and have a family history of diabetes the phlegm dampness syndromes group(n = 74),with no family history of diabetes phlegm dampness syndromes group(n = 463),with no family history of diabetes of phlegm dampness syndromes group(n= 236),The general clinical characteristics,reproductive endocrine hormones and glucose and lipid metabolism indexes of each group were compared and analyzed statistically.Results:1.Among the 1007 PCOS patients in this study,308 had a family history of diabetes,accounting for 30.59% of the total number of patients,among which 234 had a family history of diabetes,accounting for 23.24% of the total number of patients.There were 74 patients with family history of diabetes in the non-phlegm-dampness syndrome group,accounting for 7.35% of the total population.There were 463 patients without family history of diabetes in phlegm and dampness syndrome group,accounting for 45.98% of the total population.There were 236 patients without family history of diabetes,accounting for23.43% of the total.2.There were 176(57.14%)paternal patients with PCOS diabetes,121(39.28%)maternal patients with diabetes,11(3.58%)parents with diabetes,136(58.12%)paternal patients with PCOS with family history of diabetes,88(37.61%)maternal patients,40(54.06%)paternal and 33(44.59%)maternal patients with PCOS without family history of diabetes.3.Compared with the group with no family history of diabetes and no phlegm-dampness syndrome,the age of the two phlegm-dampness syndrome groups was higher,and the difference was statistically significant(P<0.05).The lowest mean age of menarche in the phlegm-dampness syndrome group with a family history of diabetes was(12.99±1.78)years old,which was statistically significant compared with the other three groups(P<0.05).The age of menarche in the phlegm-dampness syndrome group without family history of diabetes was significantly lower than that in the non-phlegm-dampness syndrome group without family history of diabetes(P<0.05).SBP,DBP,body weight,BMI,WC and HC in the two phlegm-dampness syndrome groups were all higher than those in the two non-phlegm-dampness syndrome groups,with statistically significant differences(P<0.05).WC in the non-phlegm-dampness syndrome group with a family history of diabetes was higher than that in the non-phlegm-dampness syndrome group without a family history of diabetes,and the difference was statistically significant(P<0.05).There was no significant difference in height and WHR between the four groups(P>0.05).4.The rates of acanthosis nigricans score,incidence and lipid spill in the two phlegm-dampness syndrome groups were higher than those in the two non-phlegm-dampness syndrome groups,with statistically significant differences(P<0.05).The hairy score and incidence rate of the phlegm-dampness syndrome group with family history of diabetes were lower than that of the non-phlegm-dampness syndrome group without family history of diabetes,and the difference was statistically significant(P<0.05).There was no statistically significant difference in acne score and incidence between the four groups(P>0.05).5.SHBG in the non-phlegm-dampness syndrome group with family history of diabetes was lower than that in the non-phlegm-dampness syndrome group without family history of diabetes,and the difference was statistically significant(P<0.05).LH,LH/FSH and SHBG in the two phlegm-dampness syndrome groups were lower than those in the two non-phlegm-dampness syndrome groups,and the difference was statistically significant(P<0.05).T value of phlegm-dampness syndrome group with family history of diabetes wassignificantly higher than that of non-phlegm-dampness syndrome group without family history of diabetes,with statistically significant difference(P<0.05).T value in the phlegm-dampness syndrome group without family history of diabetes was higher than that in the non-phlegm-dampness syndrome group without family history of diabetes and the non-phlegm-dampness syndrome group with family history of diabetes,the difference was statistically significant(P<0.05).The FSH,DHEAS AND AND levels between the four groups were not statistically significant(P>0.05).6.Fasting blood glucose,60 min blood glucose,120 min blood glucose,180 min blood glucose,HOMA-IR,fasting insulin and 180 min insulin in the phlegm and dampness syndrome group were all higher than the other three groups,with statistically significant differences(P<0.05).The level of insulin in 60 minutes and 120 minutes in the phlegm-dampness syndrome group was higher than that in the two non-phlegm-dampness syndrome groups,and the difference was statistically significant(P<0.05).Blood glucose in the phlegm-dampness syndrome group with a family history of diabetes was higher than that in the non-phlegm-dampness syndrome group at 30 minutes,regardless of phlegm-dampness syndrome or non-phlegm-dampness syndrome,the difference was statistically significant(P<0.05).Fasting blood glucose,60 minutes blood glucose,HOMA-IR,fasting insulin,60 minutes insulin,120 minutes insulin and 180 minutes insulin in the phlegm-dampness syndrome group without family history of diabetes were higher than those in the non-phlegm-dampness syndrome group with family history of diabetes,with statistically significant differences(P<0.05).Fasting blood glucose,30 minutes of blood glucose,60 minutes of blood glucose,120 minutes of blood glucose,HOMA-IR,fasting insulin,60 minutes of insulin,120 minutes of insulin and 180 minutes of insulin in the phlegm-dampness syndrome group without family history of diabetes were higher than those in the non-phlegm-dampness syndrome group without family history of diabetes,with statistically significant differences(P<0.05).There was no statistically significant difference in insulin level between the four groups at 30 minutes(P>0.05).7.TC in the phlegm-dampness syndrome group with family history of diabetes was higher than that in the phlegm-dampness syndrome group without family history of diabetes and the non-phlegm-dampness syndrome group without family history of diabetes,and thedifference was statistically significant(P<0.05).TC in the phlegm-dampness syndrome group without family history of diabetes was higher than that in the non-phlegm-dampness syndrome group without family history of diabetes,and the difference was statistically significant(P<0.05).The levels of TG,LDL and apo-b /A 1 in the two phlegm-dampness syndrome groups were higher than those in the two non-phlegm-dampness syndrome groups,and the difference was statistically significant(P<0.05).Apo-a1 in the phlegm-dampness syndrome group with a family history of diabetes was lower than that in the PCOS patients in the two non-phlegm-dampness syndrome groups,and the difference was statistically significant(P<0.05).Apo-a1 in the phlegm-dampness syndrome group without a family history of diabetes was lower than that in the non-phlegm-dampness syndrome group without a family history of diabetes,and the difference was statistically significant(P<0.05).HDL in the phlegm-dampness syndrome group without family history of diabetes was lower than that in the non-phlegm-dampness syndrome group without family history of diabetes,and the difference was statistically significant(P<0.05).There was no significant difference in the level of apo-b between the four groups(P>0.05).Conclusion:1.The number of PCOS patients with a family history of diabetes was highest in the father,followed by the mother,and lowest in both parents.2.Family history of diabetes phlegm and dampness syndrome PCOS patients with early menstruation age.3.Family history of diabetes patients with phlegm and dampness syndrome had a high risk of abnormal glucose tolerance and the highest degree of glucose and insulin metabolic disorder.4.Family history of diabetes patients with phlegm-dampness syndrome(PCOS)had the most severe degree of insulin resistance,followed by those without family history of diabetes patients with phlegm-dampness syndrome(PCOS),and those without phlegm-dampness syndrome had the least degree of resistance.5.Elevated blood lipid TC level in patients with phlegm-dampness syndrome PCOS was associated with a family history of diabetes.6.Increased waist circumference and decreased SHBG level in PCOS patients with non-phlegm-dampness syndrome were associated with a family history of diabetes. |
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