Analysis Of Clinical Characteristics And Factors Of Encephalitis In Hospitalized Children With Herpes Angina From 2014 To 2018

Objective: To study the clinical characteristics of hospitalized children with herpangina and the risk factors of herpetic angina complicated with encephalitis.Methods:(1)Statistics of clinical data of children with herpes angina within 5 years from January 1,2014 to December 31,2018 in Xiangxi Tujia and Miao Autonomous Prefecture People’s Hospital.(2)General clinical data statistics and classification processing were performed on all cases that met the inclusion criteria.(3)Cases with complete clinical data were divided into non-encephalitis group and encephalitis group for single risk factor analysis according to whether there was concurrent encephalitis.(1)The number of hospitalized children with herpes angina mainly increased in April and peaked in May-June.In the age distribution,it is mainly at the stage of 1-3 year old children.In the gender distribution,there were 2893 males,accounting for 56.45%,and 2232 females,accounting for 43.55%.The ratio of males to females was 1.30: 1.The ethnic groups are mainly Tujia,Miao and Han.There are 2805 cases in the rural area,accounting for 54.73%,and 2320 cases in the urban area,accounting for 45.27%.(2)Most of herpes angina pneumonia oral herpes are found 3 days before the course of the disease.The majority of patients with oral herpes disappeared on days 4-7 of the course of the disease.The total number of fever days is mainly concentrated in 1-4 days.Among the 5125 patients,4971 had perfect enterovirus nucleic acid PCR test,154 were undetected,accounting for 3.00%,the test result was negative in 1918 and accounting for 37.43%,and 3053 in positive patients accounting for 59.57 %,Of which the enterovirus universal type accounted for 56.72%,Coxsackie Group A type 16 accounted for 2.17%,and EV-71 accounted for 0.68%.(3)In the single risk factor analysis of herpes angina with encephalitis,4446 cases in the non-encephalitis group and 263 cases in the encephalitis group were gender(χ2 = 1.478,P = 0.224),peripheral white blood cell count(χ2 = 1.597,P = 0.206),CRP(χ2 = 2.009,P = 0.156),liver function(χ2 = 1.724,P = 0.189),PCT(Z =-1.498,P = 0.134),BNP(χ2 = 3.088,P = 0.079),blood glucose(χ2 = 0.881,P = 0.348)and lactic acid(χ2 = 1.197,P = 0.274)were not statistically significant.The two groups of data at different ages(Z =-3.685,P = 0.000),heart rate(χ2 = 21.740,P = 0.000),respiration(χ2 = 40.586,P = 0.000),blood pressure(χ2 = 7.503,P = 0.006),Creatine kinase isoenzyme(Z =-2.62,P = 0.039),Results: enterovirus nucleic acid PCR(χ2 = 21.280,P = 0.000)data were statistically significant.Conclusions:(1)Herpetic angina mainly affects children aged 1-3 years old,with more male patients and more rural patients than urban patients.The etiology is mainly enterovirus common type,followed by coxsackie A group 16 and EV-71.(2)Oral herpes of herpes angina is usually found 3 days before the course of the disease.Oral herpes disappears within 4-7 days of the course of the disease and the total fever time is between 1-4 days.(3)The single risk factors for herpes angina with encephalitis include gender,peripheral white blood cell count,CRP,liver function,PCT,BNP,blood glucose,and lactate.The single risk factors for herpes angina with encephalitis include 1-3 year old children,increased heart rate,increased breathing,increased blood pressure,CK-MB between 20 U/L-40 U/L,and enterovirus Type,EV-71.