The Eeg Characteristics Of Herpes Simplex Virus Encephalitis

ObjectiveHerpes Simplex Virus EncephalitisHerpes simplex virus encephalitis is caused by herpes simplex virus infection. Herpes virus type Ⅰ in adults (non-genital type), while newborn is type Ⅱ (genital type). Although primary infection may have caused HSE (Herpes simplex virus encephalitis), but most are latent virus (latent in the trigeminal ganglion or the stellate cells) reactivation or infection caused by a new virus beads. Way the virus enters the brain tissue:Ⅱ Multi blood line spread, Ⅰ type mainly through the trigeminal nerve and the olfactory nerve. Widely distributed in the brain lesions, mainly affects middle temporal lobe, frontal orbital plane and the limbic system (including the hippocampus, amygdala, entorhinal cortex, insula and cingulate gyrus), sometimes occipital lobe, hypothalamus, medulla and pons also can be involved, the extent of damage on both sides often has asymmetry. The main characteristics of pathological changes in brain tissue is hemorrhagic necrosis neurons and glial nuclei Cowdry A type inclusion bodies containing the herpes virus particles and antigens; addition to visible deformation of neurons, gliosis perivascular lymphocytic and plasma cell infiltration and edema surrounding brain lesion changes. At present, diagnosis of the disease by EEG, cerebrospinal fluid imaging and other tests, we hope that through this article for further research about the method for early diagnosis of HSE.EEG (electroencephalogram, EEG) is the sum of the records from the extracranial or intracranial scalp to the local electrical activity of neurons. EEG activity produced mainly from postsynaptic potentials. In addition, certain neurons endogenous outbreak gaps and potential links between neurons (electrical synapses) also constitute some of the ingredients of EEG activity. From the1940s, EEG began to enter clinical application. Development up to now, has been widely applied to EEG seizures, the diagnosis of central nervous system-related infectious diseases cerebrovascular disease, brain tumors, genetic and metabolic diseases and neurological degeneration and other diseases.Early diagnosis, treatment and prognostic monitoring process of disease plays an important role.We hope that through this article to further explore the clinical significance of herpes simplex virus encephalitis early EEG diagnosis.Methods1. Collection Neurology150encephalitis patients during2013.01-2014.06According to case inclusion criteria, namely the150encephalitis patients were divided into81non-HSE patients,69patients with HSE.2. According to the degree of abnormal EEG diagnostic criteria, respectively HSE patients, non-HSE patients EEG divided into:mildly abnormal, moderately abnormal, severe abnormalities, normal four. SPSS21.0software using the data in Table1Ridit analysis, observed in patients with non-HSE and HSE patients had no difference in the degree of EEG abnormalities.3. The main waveform appears EEG findings of non-HSE and HSE patients were respectively divided into:θ wave predominant (Single, bilateral),δ wave predominant (Single, bilateral), PLEDS (Single, bilateral), normal waveform. Two sets of data on chi-square test,differences were analyzed by between the HSE group and non-HSE group.4. Classifing the two group patients accroding to the appearance of the total number of EEG of the θ waves(Single, bilateral),8waves(Single, bilateral), PLEDS waves(Single, bilateral),.Analysising of the appearance times of the varity EEG waves of early (≤3days) and acute stage (4to14days), whether the EEG waveforms of the two groups was statistically different.Result1.1.HSE group R1=0.2625, non-HSE group R2=0.3436, u=0.207(P>0.05), the difference was not statistically significant, that still can not believe HSE group and non-HSE group have differences on EEG abnormalities degrees.2.95%of confidence interval between HSE group and non-HSE group is (0.00-0.02), we can see P<0.05, there is statistically significant differences between the two groups, namely there are major differences between HSE group and non-HSE Group in the waveform.3. Early stage:there is statistical difference on θ wave predominant (Single)、δ wave predominant (Single) between HSE and non-HSE patients.There is no statistical difference on θ wave predominant (bilateral)、δ wave predominant (bilateral) and PLEDS (bilateral) between HSE and non-HSE patients.Acute stage:There is no statistical difference between HSE and non-HSE patients.Conclusion1.Viral encephalitis EEG abnormalities88%, herpes simplex virus encephalitis early EEG abnormality rate of90%.2.There is difference between HSE and non-HSE on θ wave predominant (Single)、δ wave predominant (Single) and PLEDS (Single).3.Early stage:there is difference between HSE and non-HSE on θ wave predominant (Single) and δ wave predominant (Single).Acute stage:there is no difference between HSE and non-HSE..