| Objective:To investigate the dynamic changes of post-natal weight gain of very low birth weight infants(VLBWI)in our hospital,and calculate the current status of intrauterine growth retardation(IUGR)and extrauterine growth retardation(EUGR),and explore the related risk factors of EUGR.Methods : The perinatal data,growth indicators,nutrition,postnatal diseases and biochemical indicators of 156 cases of VLBWI treated in the neonatal intensive care unit(NICU)of the First Affiliated Hospital of Bengbu Medical College from January2017 to October 2019 were retrospectively collected.On the one hand,measure the body weight week after week and converts body weight to the corresponding Z value,draw the overall change curve of weight Z value,and thendivides the children into IUGR and non-IUGR,EUGR and non-EUGR subgroups,draw the Z value curve of each subgroup.On the other hand,observe the incidence of IUGR and EUGR,and compare whether there was any difference in the incidence of IUGR and EUGR between different birth weights and different gestational ages.Finally,separate the data of the two groups of children in EUGR and non-EUGR Factor analysis,independent variables with P<0.05 were included in the logistic regression model to find independent risk factors for EUGR.Results : 1.A total of 156 VLBWI cases were included,with a Z-value at birth(-1.03±0.94)and a Z-value at discharge(-2.19±0.93).The Z-value at each week after birth was <0.The overall Z value of the children showed a decreasing trend.The change trend between IUGR and non-IUGR,EUGR and non-EUGR subgroups was similar to the overall,and the Z value of body weight of IUGR and EUGR was lower.2.Of the 156 VLBWI cases,65 were IUGR,and the incidence was 41.67%;82 cases were EUGR at discharge,and the incidence was 52.56%.EUGR occurred at a higher rate in the IUGR group at discharge(80.00%).3.Divide VLBWI into four groups according to gestational age: <28 weeks,28~,32~,34~.The incidence of IUGR evaluated by weight reached 100%,51.9%,37.8% and 21.2%;the incidence of EUGR by weight was 100%,66.20%,40.00%,and36.40%,respectively.The incidences of IUGR and EUGR were negatively correlated with gestational age at birth,and there were significant differences between the 4groups(Z=2.281,P=0.023;Z=2.393,P=0.017).4.Divide VLBWI into three groups according to birth weight: <1000g,1000g~1249g,1250g~1499g The incidence of IUGR evaluated by weight was 100%,66.7% and 29.9%,and the incidence of EUGR is 100%,79.2% and 40.2%.The incidences of IUGR and EUGR were negatively correlated with birth weight,and there were significant differences between three groups(Z=4.453,P<0.000;Z=4.580,P<0.000).5.Analysis the various datas between the IUGR and non-IUGR groups: IUG R group had a higher incidence of pregnancy-induced hypertension,lower gestati onal age and birth weight,a greater proportion of diseases after birth,and longe r assisted ventilation,the above indicators had significant differences between two groups.6.Analysis the various datas between the EUGR and non-EUGR groups:pregnancy pregnancy,gestational age,birth weight,discharged weight,age at which birth weight was restored,asphyxia,NRDS,IUGR,assisted ventilation time,oxygen time,and total oral feeding time and admission PA concentration were statistically different between the two groups.Including the above indicators in logistic regression analysis,we found that low birth weight,low gestational age,and IUGR were high risk factors for EUGR at discharge(OR=0.992,P=0.049;OR=0.761,P=0.039;OR=4.758,P=0.002).Conclusion:1.Based on weight evaluation,the incidences of IUGR and EUGR were41.67% and 52.56%,which was at a relatively high level.The growth and development status was still not optimistic.2.A part of EUGR was a continuation of IUGR.3.The risk factors of EUGR when VLBWI was discharged include low birth weight,low gestational age and IUGR. |
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