| Objective:To clarify the efficacy of Mongolian medicine Jixiang Ankun Pill(Wuliji-18)in the treatment of adenomyosis through clinical study,and provide clinical basis and support for further research,development and utilization of this medicine,as well as prove the prominence of traditional Mongolian medicine,so as to further explore a safe,effective and reasonable treatment of adenomyosis.Methods:60 patients with adenomyosis treated in the Affiliated Hospital of Inner Mongolia University for Nationalities from November 2018 to November 2019 were randomly divided into two groups:30 patients in experiment group(oral administration of Mongolian medicine Jixiang Ankun Pill)and 30 patients in control group(oral administration of mifepristone tablets).Both control group and experiment group were treated for 3 months as a course of treatment.The indexes of the patients in experiment group and control group were detected and evaluated before and after treatment,including the pain symptoms assessed by visual analogue scale/score(VAS)and verbal rating scale(VRS).At the same time,the uterine changes of the two groups were observed(ultrasound examination to compare endometrial thickness and uterine volume),menstrual volume and menstrual improvement.The related complications such as gastrointestinal reaction and liver or kidney function abnormality were followed up,and the patient satisfaction was objectively evaluated by the score of self-made patient satisfaction scale.Database was established,and software SPSS 20.0 was used for statistical data processing.Statistical methods such as t-test and analysis of variance were used to analyze the results,for the changes of the above related indicators and clinical significance.Results:(1)There was no significant difference in relevant clinical data(such as age,course of disease,type of disease,gravidity,uterine leiomyoma,history of abdominal operation,education degree,etc.)between the two groups(P>0.05).(2)The total effective rate of experiment group was 28 cases(93.33%),and that of control group was 83.33%.The total effective rate of the experiment group was significantly higher than that of control group(P<0.05).(3)There were significant differences in VAS and VRS scores between the two groups before and after treatment,and there were also significant differences in VAS scores between the two groups(P<0.05).In addition,there were significant differences in the scores of VRS between the two groups before and after treatment as well as between the two groups after treatment(P<0.05).(4)There were significant differences in endometrial thickness,uterine volume,menstrual volume and menstrual improvement in experiment group before and after treatment(P<0.05).While in control group,there was no significant difference in endometrial thickness before and after treatment(P>0.05),but there were significant differences in uterine volume,menstrual volume and menstrual period improvement(P<0.05).In addition,the clinical indexes such as endometrial thickness,uterine volume,menstrual volume and menstrual improvement in experiment group were significantly better than those in control group after treatment,the difference was statistically significant(P<0.05).(5)There was significant difference in self-evaluation of overall curative effect between the two groups(P<0.05).(6)There was a significant difference in the total satisfaction between the two groups before and after treatment(P<0.05).(7)The patients in experiment group and control group were followed up for three months using SF-36 scale.Through the understanding of the health status of the patients,it was found that the total scores of experiment group before and after treatment were 62.39±8.92 and 83.48±13.59,respectively;the total score of control group before and after treatment were 62.20±9.01 and 70.49± 11.23,respectively.As for this,there was significant difference between the two groups(P<0.05).Conclusion:Mongolian medicine Jixiang Ankun Pill has a satisfactory effect in the treatment of adenomyosis,which can improve the clinical symptoms and signs of patients with adenomyosis and has a good analgesic effect in some extent.It can not only relieve the symptoms of dysmenorrhea,but also regulate the disorder of menstruation,and the effect of improving menstruation is particularly significant compared with control group.In addition,Mongolian medicine Jixiang Ankun Pill is relatively safe,with high acceptance by patients,which provides a reliable clinical basis for the prevention and treatment of adenomyosis. |
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