| Objective: to observe the effects of Whole adjustment acupuncture on bone metabolism PINP and β-CTX in primary osteoporosis,and to explore the synergistic effect and mechanism of Whole adjustment acupuncture in the treatment of primary osteoporosis.Methods: 72 patients with primary osteoporosis who met the inclusion criteria were randomly divided into treatment group(36 cases)and control group(36 cases)by random number table method.The control group was given alen sodium phosphate(70 mg/ tablet),1 tablet/time/week for 3 months.Treatment group in the control group on the basis of the use of the whole adjustment acupuncture treatment,treatment twice a week,continuous treatment for 3 months.After the treatment,the changes of pain score,TCM clinical symptoms score,quality of life scale score,bone mineral density,bone metabolism index PINP and clinical β-CTX in the two groups were observed and compared.The comprehensive clinical efficacy evaluation standard was mainly the standard for the diagnosis and efficacy of TCM internal diseases.Adverse reactions and adverse events were observed and recorded throughout the treatment.After the data of this study were summarized,spss24.0 software was used for statistical data analysis.Results:(1)baseline analysis:Gender(P= 0.567),age(P= 0.977),disease duration(P= 0.382),body mass index(P=0.314),TCM syndrome type(P= 0.86),pain score(P=0.938),TCM syndrome score(P=0.629),quality of life scale score(P= 0.79),bone density(P= 0.717),PINP(P= 0.537),and den-ctx(P= 0.702).After comparison,there was no significant difference in the data of each group(P > 0.05),which was comparable.(2)fall analysis:In the treatment group,1 patient failed to adhere to the treatment due to long-term business trip,and 1 patient withdrew from the clinical trial due to taking drugs affecting bone metabolism.In the control group,1 case quit because of unbearable acupuncture pain,and 1 case quit automatically because of urgent need to go out for treatment,with a total of34 cases completed and 2 cases lost,with a loss rate of 5.5%.In the course of the study,4cases were lost in the two groups,and the loss rate was 5.6%(4/72).(3)comprehensive clinical efficacy evaluation and analysis:Treatment group after treatment the total effective rate was 91.18%(20 cases of clinical control,6 cases were Obvious,5 cases were effective,3 cases of invalid),the control group after treatment the total effective rate was 58.82%(9 cases of clinical control,6 cases were Obvious,5 cases were effective,14 cases of invalid),(P = 0.01 < 0.05),the difference is statistically significant,indicating that the synthetic evaluation of clinical curative effect of treatment group was obviously higher than the control group.(4)intra-group and inter-group comparison of clinical symptoms(pain score,TCM syndrome score and quality of life scale score):Comparison within the group: the pain score of the treatment group before and after treatment was(4.53±1.67),(2.91±0.90),and the control group before and after treatment was(4.50 ± 0.42),(3.94±1.27).The TCM syndrome score in the treatment group was(7.97±2.50)and(5.29±1.73)before and after treatment,respectively,while that in the control group was(8.18±2.22)and(6.79±2.09)before and after treatment.The scores of life quality before and after treatment were(61.09 ± 6.92)and(44.24 ± 6.47)in the treatment group,and(60.62±7.59)and(52.24±7.22)in the control group.According to the test,there were significant statistical differences in each group(P<0.05),indicating that both groups could improve the clinical symptoms of POP patients,relieve the pain of POP patients,reduce the TCM syndrome score of POP patients,and improve the quality of life of POP patients.Comparison between groups: the pain scores of the treatment group and the control group were(2.91±0.90)and(3.94±1.27),respectively.The TCM syndrome scores of the treatment group and the control group were(5.29±1.73)and(6.79±2.09),respectively.The scores of quality of life scale in the treatment group and the control group were(44.24± 6.47)and(52.24 ± 7.22),respectively.According to the test,there were significant statistical differences in each group(P<0.05),indicating that the treatment group could improve the clinical symptoms of POP patients more than the control group,and effectively relieve pain,reduce TCM syndrome score,and improve the quality of life.(5)intra-group and inter-group comparison of bone mineral density:Comparison within the group: before and after treatment,the treatment group was(0.698 ±0.042),(0.755 ±0.074),and before and after treatment,the control group was(0.702±0.037),(0.709±0.032).In the control group,P > 0.05,the difference was not statistically significant,indicating that the treatment group could improve the bone mineral density of patients,and the change of bone mineral density before and after treatment in the control group was not statistically significant.Comparison between groups: the treatment group and the control group were(0.755± 0.074)and(0.709 ± 0.032),respectively.Upon examination,P < 0.05 showed statistically significant differences,indicating that the treatment group could improve the bone mineral density of POP patients more than the control group.(6)intra-group and inter-group comparison of bone metabolism index PINP and β-CTX group:Comparison in the group: on the bone formation markers PINP,before and after treatment in the treatment group were(42.62±7.71)and(49.50±3.27),and before and after treatment in the control group were(43.87±8.90)and(44.43±7.89),respectively.P > 0.05 in the control group showed no statistical significance,indicating that the control group had no statistical significance in improving the bone formation marker PINP in the bone metabolism of POP patients,while the treatment group had an obvious effect.On the bone resorption marker β-CTX,the treatment group was(0.59±0.11)and(0.46±0.10)before and after treatment,and the control group was(0.58±0.12)and(0.52±0.11)before and after treatment,respectively.Upon examination,there was a significant statistical difference between the two groups(P<0.05),indicating that both groups could reduce bone resorption marker β-CTX.Comparison between groups: the bone formation markers in the PINP treatment group and the control group were(49.50 ± 3.27)and(44.43 ± 7.89),respectively;the bone resorption markers in the abc-ctx treatment group and the control group were(0.46±0.10)and(0.52 ± 0.11),respectively.The results showed significant statistical differences(P<0.05),indicating that the treatment group was more able to reduce the bone resorption marker β-CTX and improve the bone formation marker PINP than the control group.(7)safety observation:During the treatment of POP patients in this study,no significant adverse reactions or other serious complications were found in the treatment group or the control group due to the medication,treatment or other reasons in this study.Conclusion:1.Whole adjustment acupuncture can reduce the bone resorption marker β-CTX in bone metabolism and improve the bone formation marker PINP.2.The combination of Whole adjustment acupuncture and alun sodium phosphate can significantly relieve the pain of POP patients,improve the clinical symptoms of traditional Chinese medicine,improve the quality of life,improve bone mineral density,reduce the resorption marker β-CTX,and improve the bone formation marker PINP.The results showed that the combination of whole adjustment acupuncture and alen sodium phosphate had a synergistic effect on POP patients,and the effect was better than that of alen sodium phosphate alone.The mechanism may be related to the fact that the overall regulation of acupuncture can significantly reduce bone resorption index of β-CTX and improve bone formation index of PINP,thus inhibiting bone resorption and promoting bone formation.3.The overall adjustment needle method has good safety and can be promoted in relevant clinical departments. |
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