| Objective:By observing the clinical efficacy of shutiaojianzhong decoction in the treatment of delayed vomiting of liver-stagnation and spleen-deficiency type after chemotherapy for colorectal cancer and monitoring its safety indexes,a new idea and method were sought for the treatment of patients with delayed vomiting after chemotherapy for colorectal cancer.Method:In this study,a total of 60 patients who met the inclusion criteria were selected and randomly divided into the treatment group and the control group,each with 30 patients.Among them,the treatment group was given shutiaojianzhong decoction(150ml/ bag,1bag/time,3 times/day)at 30 minutes after the meal and metoclopramide tablets(10mg Po tid)before the meal.The control group was given metoclopramide tablets(10mg Po tid)before meals.Patients in both groups received one course of treatment within 5 days.After one course of treatment,changes in the degree of vomiting,appetite grade,main symptom score,total score of syndromes,cartesian score,and safety indexes of patients before and after taking the drug were observed.Result:1.Degree and efficacy of vomiting before and after treatment: after taking the medicine,the degree of vomiting in both groups was lower than that before(P < 0.05),and the degree of vomiting in the treatment group was significantly lower than that in the control group(P < 0.05).The total effective rate of vomiting in the treatment group and the control group was 93% and 80%,respectively,and the curative effect in the treatment group was better than that in the control group(P < 0.05).2.Appetite grading and efficacy before and after treatment: After taking the medicine,the appetite grade of the two groups was lower than before(P < 0.05),and after taking the medicine,the appetite grade of the treatment group was lower than that of the control group(P < 0.05);after taking the medicine,the total effective rate of vomiting appetite in the treatment group and the control group was 90% and 40%,respectively,and the improvement of appetite effect in the treatment group was better than that in the control group(P < 0.05).3.The main symptom scores before and after medication,medication treatment group after nausea,vomiting,poor appetite,depressed,often abdominal distension full,chest pain,loose stool or diarrhea earlier were improved(P < 0.05),the control of nausea,vomiting,poor appetite,often abdominal distension full earlier were improved(P < 0.05),while the depressed,chest pain,loose stool or diarrhea earlier not been improved significantly(P > 0.05);After taking the medicine,the treatment group was better than the control group in improving the scores of main symptoms(P < 0.05).4.Total score of syndromes before and after treatment and its efficacy: both the treatment group and the control group reduced the total score of syndromes after treatment(P < 0.05),and the total score of reduced syndromes after treatment was better than that of the control group(P < 0.05).The total effective rate of clinical syndrome in the treatment group and the control group was 93% and 63%,respectively,and the improvement degree of clinical syndrome in the treatment group was better than that in the control group(P < 0.05).5.Cartesian score before and after treatment: both the treatment group and the control group improved cartesian score after taking the medicine(P < 0.05),and the improvement degree of cartesian score in the treatment group was higher than that in the control group(P < 0.05).6.Safety indicators before and after treatment: WBC,HGB,PLT and ALT,AST,BUN and Cr in the two groups were lower than before(P < 0.05),and there was no significant change in ALT,AST,BUN and Cr(P > 0.05).There was no significant change in RBC in the treatment group(P > 0.05),and in the control group(P < 0.05).After taking the medicine,the two groups of patients were compared with each other in terms of safety indexes.The decrease of WBC,RBC,HGB and PLT values was reduced in the treatment group compared with the control group(P < 0.05),while there was no significant difference in the changes of ALT,AST,BUN and Cr between the two groups(P > 0.05).All the above safety indexes were within the safety range before and after taking the medicine,indicating that the use of the medicine in both groups did not endanger the safety of patients.Conclusion: 1.Shutiaojianzhong decoction can effectively reduce the degree of delayed vomiting and improve the appetite of patients with liver depression and spleen deficiency type after chemotherapy for colorectal cancer.The effect of the combination of traditional Chinese and Western Medicine Group on delayed vomiting and appetite is better than that of the group with metoclopramide alone.2.Shutiaojianzhong decoction can effectively relieve the clinical symptoms of traditional Chinese medicine(such as nausea,vomiting,tolerance,mood depression,abdominal distension,chest pain,etc.),and improve the quality of life of patients.3.Shutiaojianzhong decoction can reduce the decreasing trend of WBC,RBC,HGB and PLT values after chemotherapy for colorectal cancer.4.Shutiaojianzhong decoction has a definite curative effect,no obvious adverse reactions,and is safe in clinical application.It is worth popularizing and applying. |
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