Study On The Correlation Between Monocyte/high Density Lipoprotein Ratio And The Severity Of Coronary Atherosclerosis

Background: The mortality and morbidity of coronary artery disease are quite high.The basic cause of coronary artery disease is coronary atherosclerosis.Studies have shown that inflammation plays an important role in atherosclerotic thrombosis and atherosclerotic plaque rupture.Monocytes play a central role in the pathophysiology of atherosclerosis,and its activation is an important step in initiating the atherosclerotic process.In addition to its ability to promote the efflux of cholesterol from cells,HDL also has anti-inflammatory,antioxidant,and antithrombotic effects.In addition,HDL inhibits monocyte activation and distribution and inhibits activated monocytes.The author believes that the ratio of monocyte/high density lipoprotein in coronary artery disease may be better than single monocyte number or high density lipoprotein level,and it is a predictor of the occurrence and development of atherosclerosis,and can predict cardiovascular events.Objective: We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio(MHR),an easily available inflammatory and oxidative stress marker,is associated with SYNTAX score.Methods: In this cross-sectional study,n=342 consecutive patients with coronary artery disease were classified into two groups,low SYNTAX score(≤ 22)and high SYNTAX score(≥ 23).Results: MHRs were significantly higher in patients with high SYNTAX score(p<0.05).In multivariate regression analysis,MHR remained as independent predictor of high SYNTAX score together with C-reactive protein(CRP),hypertension and diabetes mellitus.In correlation analysis,MHR showed significant positive correlations with SYNTAX score(r = 0.383,p<0.001)and CRP level(r = 0.416,p<0.001).Conclusion: This study suggests MHR is independently associated with burden of coronary atherosclerosis.