Clinical Observation Of Huichun Jianwei Decoction In The Treatment Of Chronic Atrophic Gastritis

Objective To observe the clinical efficacy and safety of Professor Gan Aiping’s Huichun Jianwei Decoction in the treatment of chronic atrophic gastritis with spleen,stomach and qi-yin deficiency(spleen-stomach weakness syndrome and stomach-yin deficiency syndrome),and explore its pathological mechanism.Methods Patients from Hubei Provincial Hospital of Traditional Chinese Medicine from December 2017 to June 2019 were diagnosed as chronic atrophic gastritis through gastroscopy and histological examination,and 64 patients with syndromes of deficiency of spleen,stomach,qi and yin were identified by TCM.Cases;divided into 2groups according to the random table method,32 cases in the treatment group and the control group.Before and after treatment,the patients in the two groups underwent routine hematuria,electrocardiogram,and liver and kidney function tests.The treatment group was given oral Chinese medicine Huichun Jianwei Decoction,and the control group was given Weifuchun.Patients are revisited once a week,dialectical additions and subtractions are made according to the clinical situation of the patients,and the clinical symptoms scale score of the patients is improved.After24 weeks of treatment,gastroscopy and histopathological examination were performed after the course of treatment.The clinical symptoms and pathological histology(chronic inflammation,atrophy,intestinal change)of the two groups of patients were compared before and after treatment,and the safety after taking the drug was compared.Results(1)There were no significant differences in clinical data such as gender,age,course of disease and clinical symptoms,gastroscopy results,and histopathological scores between the two groups of patients(P> 0.05),and the data were comparable.(2)TCM clinical symptom scores: After treatment,the TCM symptom scores were compared between the two groups and there was a statistical difference(P <0.05);after treatment,the TCM symptom scores were compared between the two groups and there was a statistical difference(P < 0.05),the treatment group was significantly better than the control group.(3)Comparison of the efficacy of TCM symptoms: After treatment,the symptoms in both groups were alleviated.The total effective rates of the treatment group and the control group were 93.54% and 70.76%,respectively.There was a significant statistical difference in the comparison of TCM symptoms between and between the two groups(P <0.05).(4)Comparison of the efficacy of gastroscopy: After treatment,the gastric mucosa of both groups improved.The total effective rates of the treatment group and the control group were 83.87% and 64.51%,respectively.There was a statistical difference in the efficacy of gastroscopy within and between the two groups(P <0.05).(5)Comparison of pathological scores between the two groups: There was a statistical difference in the atrophy and intestinal pathological scores of the treatment group before and after treatment(P <0.05),and there was no significant statistical difference in the comparison of the intestinal pathological scores of the control group before and after treatment(p> 0.05).);Compared between the two groups after treatment,the atrophy and intestinal improvement in the treatment group were significantly better than those in the control group,with statistical differences(P <0.05);(6)Comparison of pathological effects between the two groups: mucosal atrophy and intestinal treatment in the treatment group after treatment The total effective rates were 77.41% and 64.51%,and the total effective rates of mucosal atrophy and intestinalization after treatment in the control group were 58.06% and 48.38%,respectively.There was a statistically significant difference between the two groups(P <0.05).In the control group.(7)Safety observation: During the treatment period,there were no obvious adverse reactions in both groups.Conclusion The traditional Chinese medicine Huichun Jianwei Decoction has a significant effect on the treatment of chronic atrophic gastritis of spleen,stomach and qi and yin deficiency,which significantly improves the clinical symptoms of patients,reduces gastric erosion and inflammation,and even reverses the intestinal metaplasia and atrophy.small.