Aquaporin-4 Antibody And Clinical Characteristics Of Neuromyelitis Optica Spectrum Disorders Correlation Analysis

Objective: To explore the difference of clinical characteristics between the positive and negative groups of aquaporin-4 antibody in patients with neuromyelitis optica spectrum disorders,so as to provide some ideas for the diagnosis and treatment of NMOSD.Methods: To collect 93 cases of NMOSD from January 2016 to August 2019 in the First Affiliated Hospital of Xinjiang Medical University.They were divided into AQP4-IgG positive group and AQP4-IgG negative group.Their clinical characteristics were analyzed retrospectively,including gender,age of onset,first symptom,recurrence,inducement,combined autoimmune diseases,biochemical tests for cerebrospinal fluid,autoimmune antibodies,inflammatory indicators and imaging characteristics.Results: There are more women in the AQP4-IgG positive group than in the AQP4-IgG negative group(P<0.05).The average age of onset in the AQP4-IgG positive group are older than that in the AQP4-IgG negative group(P<0.05).The number of relapses in the AQP4-IgG positive group are larger than that in the AQP4-IgG negative group(P<0.05).Spinal cord injury with more than6 and less than 10 vertebral body segments is more common in AQP4-IgG positive group than that in AQP4-IgG negative group(P<0.05).The ANA antibody is more common in the AQP4-IgG positive group than the AQP4-IgG negative group(P<0.05).There is no significant difference between the two groups in inducing factors,first symptoms,time from first attack to relapse,distribution of spinal cord lesions,CSF pressure,number of white blood cells,glucose,protein,chlorine,adenosine deaminase,autoimmune diseases,C-reactive protein,ceruloplasmin,? l antitrypsin.Conclusion: AQP4-IgG-positive NMOSD patients have more women than those with negative AQP4-IgG.They are older and more prone to relapse.ANA antibodies and Spinal cord injury with more than 6 and less than 10 vertebral body segments are more common in AQP4-IgG-positive NMOSD.