| Objectives:Based on the previous studies,the study measured and compared the serum levels of Visfatin and A-FABP in Hani and Naxi residents,and analyzed the factors that may affect the levels of serum Visfatin and A-FABP in Hani and Naxi residents.The relationship between serum Visfatin and A-FABP levels in Hani and Naxi residents and hypertension,diabetes,obesity,and dyslipidemia provides new ideas for early prevention and clinical diagnosis of NCD.Methods:The multistage stratified random sampling method was conducted to determine the research site and the research subjects;Collecting basic information such as demographic characteristics and dietary nutrition status of two ethnic residents through questionnaires and dietary surveys,Obtain basic health data and blood biochemical indicators of two ethnic residents through medical examinations and laboratory tests,The levels of serum Visfatin and A-FABP were detected by ELISA;The concentrations of Serum Visfatin and A-FABP were calculated by Sigma Plot 12.0 software;Use Epidata3.0 software to build a database and enter data;statistical analysis was performed by SPSS20.0 software,and The difference was statistically significant at P<0.05;statistical graph was drawn by GraphPad prism6 software.Results:1.Demographic characteristics of the respondents:This study investigated 960 residents of the Hani and Naxi ethnic groups,487 Hani(50.73%),473 Naxi(49.27%),371 males(38.65%),and 589 females(61.35%),the age range is 18 to 85 years old,and the average age is 50(42,62)years old.2.Comparative analysis of anthropometric and biochemical indicators of Hani and Naxi residents:There was no significant difference between HDL and LDL in the two ethnic groups(P>0.05),The other anthropometric and biochemical indicators were statistically significant between the two ethnic groups(P<0.05).3.Comparative analysis about the prevalence of four chronic diseases in Hani and Naxi:Prevalence rate of Hypertension:Hani 19.71%(95%CI:16.18%～23.24%),Naxi 31.08%(95%CI:26.91%～35.25%);Prevalence rate of diabetes mellitus:Hani 3.49%(95%CI:1.86%～5.12%),Naxi 1.48%(95%CI:0.39%～2.57%);Prevalence rate of BMI obesity:Hani 4.52%(95%CI:2.67%～6.37%),Naxi 17.76%(95%CI:14.42%～21.20%);Prevalence rate of abdominal obesity:Hani 36.55%(95%CI:32.27%～40.83%),Naxi 56.03%(95%CI:51.56%～60.50%);Prevalence rate of body fat obesity rates:Hani 30.01%(95%CI:25.94%～34.08%),Naxi:46.09%(95%CI:41.60%～50.58%);prevalence of dyslipidemia:Hani 29.57%(95%CI:25.52%～33.62%),Naxi 36.36%(95%CI:32.02%～40.70%).The prevalence of diabetes in Hani residents was higher than that in Naxi(P<0.05).The prevalence of hypertension,BMI obesity,abdominal obesity,body fat rate obesity,and dyslipidemia were lower than those of Naxi(P<0.05).4.Comparative analysis of serum Visfatin levels in Hani and Naxi residents:The serum Visfatin concentrations of Hani and Naxi residents respectively were 8.65(5.29,15.96)ng/mL and 6.01(4.09,9.00)ng/mL,and Hani residents were higher than Naxi(P<0.05).Hani:18～49 years old group and 50-64 year old group are the same(P>0.017),and both are lower than 65 years old-group(P<0.017);Naxi:18～49 year old group and 50-64 year old group are the same(P>0.017),and all were lower than 65 years old to group(P<0.017).5.Comparative analysis of serum A-FABP levels in Hani and Naxi residents:The serum A-FABP concentrations of Hani and Naxi residents were 8215.26(5603.76,11663.14)pg/mL and 9809.25(6657.89,14172.46)pg/mL,Naxi residents were higher than Hani(P<0.05).Hani:females were higher than males(P<0.05);50-64 years old and 65-year-old groups were the same(P>0.017),and were higher than 18-49 years old group(P<0.017);medium physical strength group and weight The physical strength group was the same(P>0.017),and both were lower than the light physical strength group(P<0.017);Naxi:women were higher than men(P<0.05),and non-smokers were higher than the smokers(P<0.05).6.Comparative analysis of serum Visfatin levels in four chronic patient groups of Hani and Naxi:Unless the Naxi people in the hypertension group were higher than the Hani people,the Hani residents in each group of chronic diseases were higher than those in the Naxi(P<0.05).Hani:The dyslipidemia group was higher than the non-lipidemia group(P<0.05);the high TG dyslipidemia group was higher than the non-high TG dyslipidemia group(P<0.05).Naxi:Non-hypertensive group was higher than hypertension group(P<0.05),low HDL dyslipidemia group was higher than non-low HDL dyslipidemia group(P<0.05).7.Comparative analysis of serum A-FABP levels in four chronic patient groups of Hani and Naxi:In the non-hypertension group,normal blood glucose group,BMI obesity group,non-body fat rate obesity group,non-dyslipidemia group,non-high TC dyslipidemia group,non-high TG dyslipidemia group,non-low HDL dyslipidemia group,In the non-high LDL dyslipidemia group,the serum A-FABP level of Naxi residents was higher than that of Hani(P<0.05).Hani people:hypertension group was higher than non-hypertension group(P<0.05);abdominal obesity group was higher than non-abdominal obesity group(P<0.05);body fat percentage obese group was higher than non-body fat rate obesity.The dyslipidemia group was higher than the non-lipidemia group(P<0.05);High TC dyslipidemia group was higher than non-high TC dyslipidemia group(P<0.05);High TG dyslipidemia group was higher than non-high TG dyslipidemia group(P<0.05);The obese group was higher than the normal group and super-recombination group(P<0.008),the wasting group was the same as the normal group,super-recombinant and obese group(P>0.008),the normal group is the same as the super-.recombination and obesity groups(P>0.008).Naxi people:hypertension group was higher than non-hypertension group(P<0.05);abdominal obesity group was higher than non-abdominal obesity group(P<0.05);body fat percentage obese group was higher than non-body fat rate obese group(P<0.05);the weight loss group was lower than the super-recombination and obesity group(P<0.008),the normal group was lower than the super-recombination and obesity group(P<0.008),the super-recombination was lower than the obese group(P<0.008),the thin group Same as normal group(P>0.008).8.Comparative analysis of factors affecting serun Visfatin levels in Hani and Naxi resideltsHani people:There was a positive correlation between serum Visfatin level and energy and cholesterol(P<0.05),and negative correlation with saturated fatty acids,protein and carbohydrate(P<0.05);Naxi people:There was a positive correlation between serum Visfatin level and age(P<0.05).9.Comparative analysis of factors affecting serum A-FABP levels in Hani and Naxi residents:Hani people:There was a positive correlation among serur A-FABP level,waist circumference,body fat percentage and age(P<0.05),free and other occupations were higher than farmers(P<0.05),and women were higher than men(P<0.05);Naxi people:There was a positive eorrelation between serum A-FABP level and waist circumference,systolic blood pressure,TG and body fat percentage(P<0.05).The AA genotype of PPARY2 gene Pro12Ala polymorphism was higher than PP genotype(P<0.05);There was a negative correlation with protein(P<0.05),and women were higher than men(P<0.05).10.Comparative analysis of the relationship bet.Areen serum Visfatin,A-FABP levels and chronic diseases in Hani and Naxi residents:Hani people:age,visceral fat index,TG may be a risk factor for hypertension(P<0.05);systolic blood pressure,HDL may be a risk factor for diabetes(P<0.05);visceral fat index,cholesterol may be the risk of BMI obesity Factors(P<0.05),free and other occupations had higher effects on BMI obesity than farmers(P<0.05),Primary/initial small and calcium may be protective factors for BMI obesity(P<0.05);visceral fat index,A-FABP concentration may be a risk factor for abdominal obesity(P<0.05);women’s effect on abdominal obesity was lower than that of males(P<0.05),and PPARy2 gene Pro 12Ala polymorphic PA genotype had lower effect on abdominal obesity than PP genotype(P<0.05);age,heavy physical labor intensity,visceral fat index may be a risk factor for body fat percentage obesity(P<0.05);age may be a risk factor for dyslipidemia(P<0.05);viscera Fat index may be a risk factor for high TC(P<0.05);waist circumference may be a risk factor for hypertriglyceridemia(P<0.05);effect of PPARγ2 gene Pro12Ala polymorphism PA genotype on hyper-HDLemia Higher than PP genotype(P<0.05).Naxi people:age,waist circumference,and GLU may be risk factors for hypertension(P<0.05),Women’s effects on hypertension were higher than men’s(P<0.05),Free and other occupations had higher effects on hypertension than farmers(P<0.05);LDL and zinc may be risk factors for diabetes(P<0.05);waist circumference,visceral fat index and systolic blood pressure may be risk factors for BMI obesity(P<0.05).Age,insoluble dietary fiber may be BMI obese.Protective factors(P<0.05),women had lower effects on BMI than men(P<0.05);BMI may be a risk factor for abdominal obesity(P<0.05);age,BMI,visceral fat index,fat may be body The risk factors of fat rate obesity(P<0.05),insoluble dietary fiber may be the protective factor of body fat rate obesity(P<0.05);medium physical strength,heavy physical strength,carbohydrate may be a risk factor for high TCemia(P<0.05);Visfatin concentration may be a risk factor for low HDL(P<0.05);PPARγ2 gene C161→T polymorphic site CT genotype and TT genotype have higher effects on high LDL than CC genotype(P<0,05).Conclusions:1.The prevalence of four different chronic diseases differs between the two ethnic groups.The prevalence of diabetes among Hani residents is higher than that of Naxi,hypertension,BMI obesity,abdominal obesity,body fat rate obesity,and dyslipidemia.The rate is lower than the Naxi.2.The level of serum Visfatin in Hani residents was higher than that in Naxi,and serum A-FABP levels were lower than those in Naxi.There were differences in serum Visfatin and A-FABP levels among the four chronic patients in the two ethnic groups.3.Hani:There is a positive correlation between serum Visfatin levels and energy and cholesterol,and a negative correlation with saturated fatty acids,proteins and carbohydrates.Naxi:There is a positive correlation between serum Visfatin levels and age.4.Hani:There is a positive correlation among serum A-FABP levels and waist circumference,body fat percentage,and age,Freedom and other occupations are higher than farmers;women are higher than men.Naxi:There was a positive correlation between serum A-FABP level and waist circumference,systolic blood pressure,TG and body fat percentage.The AA genotype of PPARγ2 gene ProlZAla polymorphism was higher than PP genotype;there was a negative correlation with protein,and women were higher than male.5.There were differences in serum Visfatin and A-FABP levels between Hani and Naxi residents.Serum A-FABP concentration in Hani residents may be a risk factor for abdominal obesity,Serum Visfatin concentration in Naxi residents may be a risk factor for hypo-HDL. |
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