Correlation Analysis Between Cognitive Factors And Event-related Potentials In Patients With Temporal Lobe Epilepsy

Objectives:The cognitive function(CF)of patients with temporal lobe epilepsy(TLE)was studied by applying event-related potentials(ERPs),and the correlation between cognitive function factors and outcomes of ERPs in patients with temporal lobe epilepsy was analyzed.Methods:According to the set inclusion and exclusion criteria,60 adult patients with temporal lobe epilepsy who were admitted to the Department of Neurology,First Affiliated Hospital of Kunming Medical University from July 2017 to February 2019,randomly selected 60 genders and ages.Matching healthy adults served as a control group.Collect basic information and clinical information of patients with temporal lobe epilepsy,and improve the magnetic resonance imaging(MRI),24h-video or electroencephalogram(EEG)and ERPs;60 normal adults in the normal control group ERPs check.By using the corresponding statistical methods,the differences of ERPs between the patients with temporal lobe epilepsy and the normal adult control group were analyzed,and the patients with temporal lobe epilepsy were further divided into normal cognitive function group and cognitive dysfunction group according to the test results.The influencing factors of cognitive dysfunction(CD)in patients with temporal lobe epilepsy and their correlation with the results of various components of ERPs.Results:The incidence of cognitive dysfunction in adult patients with temporal lobe epilepsy(81.67%)was significantly higher than that in normal adult controls(p<0.05).The results of ERPs were mainly N1 wave,N2 wave and P3 wave latency prolonged and decreased P3 wave amplitude(p<0.05).2.For adult temporal lobe epilepsy,patients with long course of disease are more likely to have cognitive dysfunction than patients with short course of disease.ERPs are characterized by prolonged latency of N2 and P3 waves(p<0.05);comprehensive seizures or partial patients with seizures and generalized seizures were more likely to have cognitive dysfunction than those with only partial seizures.ERPs showed a decrease in the amplitude of P3 waves(p<0.05).Patients with frequent episodes of temporal lobe epilepsy were more likely to have fewer episodes.Cognitive dysfunction occurred,and the ERPs showed a prolonged latency of P3 wave(p<0.05).Patients with combination therapy were more likely to have cognitive dysfunction than patients treated with monotherapy,and ERPs showed an prolonged latency of N2 wave(p<0.05);patients with responsible MRI were more likely to have cognitive dysfunction than those without significant abnormalities.ERPs showed prolonged latency of N1 wave,N2 wave and P3 wave(p<0.05);24h video or dynamic EEG examination Patients with epileptiform discharge or paroxysmal slow wave release and background wave abnormalities were found to be more prone to cognitive dysfunction than patients without abnormalities.The ERPs showed the prolonged latency of P3 waves.(p<0.05).The frequency of seizures and EEG results in patients with temporal lobe epilepsy were independent risk factors for cognitive dysfunction,and the effect of seizure frequency on cognitive function was greater(B>0,OR>1,p<0.05).Correlation between temporal lobe epilepsy and ERPs components parameters:The latency of N1 wave was correlated with age of onset(p<0.05);the latency of P2 wave was related to age of onset,EEG findings and course of disease(p<0.05)The latency of N2 wave was correlated with EEG findings,age of onset,and medication status(p<0.05);latency of P3 wave was correlated with EEG findings(p<0.05);amplitude and type of P3 wave and brain Electrogram examination results were correlated(p<0.05).Conclusions:1.Event-related potentials(ERPs)are the objective basis for evaluating cognitive dysfunction.Patients with temporal lobe epilepsy have a higher incidence of cognitive dysfunction than normal adults,and the results of ERPs are N1,N2,and P3.The latency is prolonged and the amplitude of the P3 wave is reduced.2.The factors influencing cognitive dysfunction in patients with temporal lobe epilepsy include:the course of temporal lobe epilepsy,the type of seizure,the frequency of seizures,the condition of patients taking anti-epileptic drugs,the results of MRI and EEG examination of patients,and the frequency of seizure and brain Electrogram abnormalities are independent risk factors.The results of the parameters of each component of ERPs reflect different degrees of cognitive impairment in patients with temporal lobe epilepsy.The influencing factors include age of onset,course of disease,type of seizure,medication status and EEG findings.Among them:the age of onset mainly affects the latency of N1 wave and P2 wave,which reflects the obstacle to the attention of patients in the early stage of cognition;the abnormal result of EEG mainly affects the latency of N2 wave and P3 wave,reflecting the late stage of cognitive disorders that stimulate response recognition and processing ability;the type of seizure(the patient has a generalized seizure)mainly affects the amplitude of the P3 wave and responds to the patient’s ability to stimulate the information memory.