Clinical Analysis Of 161 Cases Of Ulcerative Colitis

Objective:1.The clinical data of 161 patients with ulcerative colitis diagnosed in our hospital in the past 10 years were analyzed,and the differences in general conditions,clinical manifestations,serological indexes,electronic colonoscopy and histopathology were compared to provide some reference for clinical diagnosis and treatment.1.The article is intended to explore the relationship between serological indexes and the modified Mayo score,and estimate the value and significance of using them to evaluate the stage of ulcerative colitis(UC).Methods:The general data,clinical manifestations,blood routine,biochemical indexes,autoantibodies,electronic colonoscopy of 161 patients with ulcerative colitis admitted to the first Hospital of Lanzhou University from January 2008 to December 2018 were retrospectively analyzed to compare the difference of serological indexes between active UC,remission UC and patients with proctitis,left semicolitis and total colitis.The critical value of NLR,PLR and the area under the curve were calculated by the receiver operating characteristic curve.Results:1.The age of onset of UC in this study showed a double peak distribution,which was 30-40 years old and 50-60 years old.There was no gender difference in the age of onset.The majority of UC patients were urban population(59.63%),mental workers(63.98%).The clinical type was mainly primary type(42.24%)and chronic recurrent type(36.02%),and the severity of the disease was mild to moderate(81.1%).The extent of lesions is more common in left hemicolitis(54.7%).2.The incidence of body mass loss,fatigue and fever among the groups with different lesion ranges was statistically different.The main complications of UC were anemia,electrolyte disorder,colorectal polyps,intestinal obstruction and so on,thromboembolism,intestinal perforation and colorectal cancer is rare.3.Hemoglobin was statistically different between groups and groups in different lesions(P < 0.05).The lower the hemoglobin,the wider the lesion involvement.4.The NLR,PLR of active UC patients was significantly higher than that of remission stage.The area under ROC curve of NLR was 0.838(95% confidence interval: 0.763-0.912,P < 0.001),the area under ROC curve of PLR was 0.773(95% confidence interval: 0.686-0.860,P < 0.001).The optimal cut-off values of NLR and PLR in judging UC activity were 2.645 and 130.35,respectively,the sensitivity and specificity were 63.2% and 71.1%,and 89.5% and 74.2%.The sensitivity and specificity of the combination of NLR and PLR were 80.8% and 86.7%.5.There was no statistical significant difference in sex,serological index and clinical type between UC in early onset group and late onset group.Conclusion:In this study,the age of ulcerative colitis patients showed a double peak distribution,which was 30-40 years old and 50-60 years old.There was no significant difference in clinical features between the early onset group and the late onset group.Hemoglobin can be used as a reliable index to judge the extent of the lesion,and NLR,PLR can be used as an effective serological marker for monitoring the activity of endoscopy and judging whether UC is active or not,and the combination of the two is more accurate.