| Purpose:The study was designed to analyze blood test results,To explore the changes of platelite-lymphocyte ratio(PLR),neutrophil-lymphocyte ratio(NLR),monocyte-lymphocyte ratio(MLR),platelet count*neutrophil-lymphocyte count/lymphocyte count(SII)at different disease activity levels,the correlation and the prediction of disease activity Measure the value.Method:1.Research methods:A total of 195 patients with IBD admitted to the gastroenterology Department of Ganzhou People’s Hospital from December 2015 to July 2022 were chosen as the focus of the research,of which 107 were ulcerative colitis and 88 Crohn’s disease.At the same time,99 healthy patients of the medical examination department of Ganzhou People’s Hospital were selected as control group.2.Data Collection:The information of IBD patients and healthy subjects was collected,including age,gender,blood routine(including white blood cells,neutrophils,platelets,lymphocytes and other indicators),lesion site,medication history,endoscopic manifestations,etc.We divided IBD into two different disease groups.UC disease activity level was evaluated by Truelove and Witts disease severity,and CD disease activity was evaluated by simplified Crohn’s disease activity index,which was further subdivided into remission and active(mild,moderate,severe)groups.3.Statistical methods:SPSS 26.0 software was used to process the data and Kolmogorov-Smirnov test was used to test the normality of the measurement data.The normal distribution of measurement data was represented by the mean standard deviation.Group t test and ANOVA analysis were used to compare whether there was statistical difference between two groups or more than two groups.The non-normal distribution was represented by median(interquartile distance),and Mann-Whitney U and Kruskal-Wallis H tests were used to compare whether there were statistical differences between the two groups or more than two groups,and multiple comparisons of multiple groups of data were conducted by Spearman correlation analysis Finally,Receiver Operating Characteristic(ROC Curve)was constructed,and the Area Under Curve(AUC)and its 95%CI were calculated.p<0.05 was statistically significant.Results:1.IBD group of PLR,NLR,MLR,SII is higher than the control group,the difference was statistically significant(t/|Z|=10.19,11.38,8.67,10.98,p<0.05).2.UC group of PLR,NLR,MLR,SII is higher than the control group,the difference was statistically significant(t/|Z|=8.60,10.14,7.46,9.42,p<0.05).3.The CD set of PLR,NLR,MLR,SII is higher than the control group,the difference was statistically significant(t/|Z|=9.06,9.48,7.54,9.58,p<0.05).4.PLR,NLR,MLR and SII in UC active stage were higher than those in remission stage,and the difference was statistically significant(p<0.05).5.PLR,NLR,MLR and SII in active stage of CD were higher than those in remission stage,and the difference was statistically significant(p<0.05).6.In UC,PLR,NLR,MLR,and SII showed statistically significant differences in different disease activities(remission group,mild group,moderate group,and severe group)(p<0.05).Compared with remission group and mild group,PLR,NLR,MLR,and SII in severe group increased significantly,with statistically significant differences(p<0.05).7.In CD,PLR,NLR,MLR and SII showed statistically significant differences in different disease activities(remission group,mild group,moderate group and severe group)(p<0.05).Compared with remission group and mild group,PLR,NLR,MLR and SII in severe group increased significantly with statistically significant differences(p<0.05).8.In UC,PLR,NLR,MLR and SII were positively correlated with UC activity(r_s=0.561,0.500,0.447,0.675,p<0.001),and the positive correlation coefficient r of SII was the highest(r=0.675,p<0.001),which was the best positive correlation with UC disease activity.9.In CD,PLR,NLR,MLR and SII were positively correlated with CD activity(r_s=0.542,0.397,0.432,0.619,p<0.001),and the positive correlation coefficient of SII r(r=0.619,p<0.001)was the highest,which was positively correlated with the disease activity of CD.10.According to the critical value of remission and activity of UC,the ROC curve was plotted.PLR,NLR,MLR and SII all had predictive value for the disease activity of UC(p<0.05).Their areas under the curve(AUC)were 0.877,0.935,0.829and 0.915,and their Cut-off values were 153.05,2.41,0.34 and 790.77,respectively.Their sensitivity and specificity were 80.2%and 82.8%,81.2%and 91.9%,65.3%and 89.9%,74.3%and 97.0%,respectively.11.According to the simplified Crohn’s disease activity index calculation method,the ROC curve of CD was divided into critical value,PLR,NLR,MLR and SII all had predictive value for the disease activity period of CD(p<0.05).Their areas under the curve(AUC)were 0.906,0.916,0.831 and 0.933,and their Cut-off values were 142.97,2.05,0.29 and 624.00,respectively.Their sensitivity and specificity were 89.6%and 77.8%,85.7%and 82.8%,72.7%and 80.8%,83.1%and89.9%,respectively.Conclusion:1.PLR,NLR,MLR and SII were all increased in UC and CD,and significantly increased in the active stage of the disease.2.PLR,NLR,MLR and SII were positively correlated with UC and CD disease activity,and had high predictive value for disease activity,among which NLR had the highest predictive value for UC and SII had the highest predictive value for CD disease activity. |
PDF Full Text Request