Correlation Between Pulmonary Ventilation Function And Peripheral Blood Eosinophil Count In Patients With Stable COPD

Objective:To investigate whether there is a correlation between peripheral blood eosinophil count and pulmonary ventilation function（FEV₁,FVC,FEV₁/FVC,MMEF）in the subgroups of A,B,C,and D grouped according to the comprehensive evaluation method in the 2017 version of the GOLD guidelines.Methods:According to the inclusion and exclusion criteria developed in this study,120 patients with stable COPD were enrolled as study groups.The study components were divided into four subgroups A,B,C and D according to the comprehensive evaluation method in the 2017 edition of the GOLD initiative.60 patients who underwent physical examination at the same time were used as a control group.Pulmonary ventilation function（FEV₁,FVC,FEV₁/FVC,MMEF）and peripheral blood eosinophil counts were measured in the study group（four subgroups A,B,C,and D）and the control group.After 12 months of follow-up,Pulmonary ventilation function（FEV₁,FVC,FEV₁/FVC,MMEF）and peripheral blood eosinophil count were measured again in the study group（four subgroups A,B,C,and D）and the control group.Correlation analysis was performed on the obtained pulmonary ventilation function index（FEV₁,FVC,FEV₁/FVC,MMEF）and peripheral blood eosinophil count values.Results:（1）There were significant differences in peripheral blood eosinophil counts between the study groups A,B,C,and D compared with the control group（P<0.05）.There were significant differences in peripheral blood eosinophil counts among the subgroups of study groups A,B,C and D,and the difference was statistically significant（P<0.05）.Statistically significant differences were present at the time of enrollment and 12 months after follow-up.（2）There were significant differences in pulmonary ventilation function（FEV1,FVC,FEV1/FVC,MMEF）between the subgroups of group A,B,C and D compared with the control group,and the difference was statistically significant（P<0.05）.There were significant differences in pulmonary ventilation function（FEV1,FVC,FEV1/FVC,MMEF）between the subgroups A,B,C,and D in the study group,and the difference was statistically significant（P<0.05）.（3）There was a negative correlation between FEV1and peripheral blood eosinophil counts in the subgroups of groups A,B,C,and D,and the difference was statistically significant（P<0.05）.There was a negative correlation between MMEF and peripheral blood eosinophil counts in the subgroups of groups A,B,C,and D,and the difference was statistically significant（P<0.05）.There was no correlation between FVC and peripheral blood eosinophil counts in the subgroups of groups A,B,C,and D,and the difference was not statistically significant（P>0.05）.There was no correlation between FEV1/FVC in the subgroups of group A,B,C and D and peripheral blood eosinophil counts,and the difference was not statistically significant（P>0.05）.Conclusion:There was a negative correlation between peripheral blood eosinophil count and pulmonary ventilation function（FEV1,MMEF）in patients with stable COPD;Peripheral blood eosinophil counts in patients with stable COPD were not associated with pulmonary ventilation function（FVC,FEV1/FVC）.