The Research On The Correlation Between Peripheral Blood Eosinophils And AECOPD

Objective:Observe the rate of Obstructive Pulmonary Disease（AECOPD）Inpatients which Peripheral Blood Eosinophil（PBE）relative count is equal or over 2%,and execute the research of relationship between PBE and clinical features,disease classification,T lymphocyte subsets of peripheral blood,therapy and etc.to find out the correlation between PBE and the AECOPD clinical scale&outcomes.Method:Collect the cases of hospitalized AECOPD patients,total 77 cases,include male patient 51 cases,female patient 26 cases,the age is between 49 to 91 years old.Execute prospective analysis to these cases.All of the patients can meet the diagnostic criteria of COPD in Global Initiative for Chronic Obstructive Lung Disease 2018（GOLD 2018）,and in acute exacerbation.According to the PBE%,the cases have been divided into 2 groups,cases which PBE%≥2%as Peripheral Blood Eosinophil Positive Group（Group Ⅰ）,cases which PBE%<2%as Peripheral Blood Eosinophil Negative Group（Group Ⅱ）.Collect the clinical data of all patients which include personal information,past medical history,smoking history,lung function in stable phase,the in-hospital serological marker,CAT score,consumption of hormone,the condition of using noninvasive mechanical ventilation,in-hospital days and etc.Result:This research has covered 77 cases of AECOPD,Group Ⅰ 23 cases,Group Ⅱ54 cases,the patients which PBE%≥2%is 29.9%of the total,2%≤PBE%<3%is14.3%（11）,3%≤PBE%<4%is 6.5%（5）,4%≤PBE%<5%is 1.3%（1）,PBE%≥5%is 7.8%（6）;200/μl≤PBE#<300/μl is 6.5%（5）,300/μl≤PBE#<400/μl is 6.5%（5）,PBE#≥400/μl is 6.5%（5）.According to the comparation between two groups,the course of COPD of Group Ⅰ is shorter than Group Ⅱ,which has statistical significance.There is no statistic difference of gender,age,BMI,smoking history,pulmonary heart disease,complications,use of basic ICS,home oxygen therapy,worsened times in the last one year between the two groups.The PBE relative values of two groups are 3.00%（2.40%,5.10%）,1.42%（1.23%,1.97%）,absolute values are 450（200,1200）/μl,230（130,360）/μl.According to the comparation between Group Ⅰ and Group Ⅱ,the Peripheral Blood Neutrophil Granulocyte and Lymphocyte（N/L）,Hemoglobin（Hb）,C-reaction Protein（CRP）are in low level,has statistical significance（P<0.05）,the rate of AECOPD clinic scale level ⅡI patients,admission CAT score,WBC,fibrinogen（FIB）,D-Dimer,T suppressor/cytotoxic cell,arterial blood partial carbon dioxide pressure（pCO₂）,positive rate of sputum culture,non-invasive mechanical ventilation,consumption of systemic hormone,in-hospital death rate and in-hospital days are in low level,the rate of AECOPD clinic scale level I&Ⅱ,rate of platelet count（PLT）&PCT increasing,,total T cell,T helper/suppressor cell,T suppressor/cytotoxic cell,CD4/CD8,pH,partial oxygen pressure（pO₂）,saturation of oxygen(SaO₂),FEV1%pred,exhaled nitric oxide check（FeNO）are in high level,but there is no statistic difference.The absolute valve and relative value of PBE,CAT score of Group Ⅰ has decreased after treatment,the absolute valve and to GroupⅡ,relative value of PBE,N/L,pH has increased,CAT score,pCO₂ has decreased after treatment,all of them have statistical significance.The PBE relative count and absolute count of Group Ⅰ has decreased after treatment,but Group Ⅱ has increased,the difference between the two groups has statistical significance,others have no statistical significance.PBE%showed negative correlation with CRP with statistical significance,CAT,WBC,pCO₂ showed the trend which will decrease when relative count of PBE was increasing,N/L,FEV1%pred,pH,pO₂,SaO₂ showed the trend which will increase when relative count of PBE was increasing,but all without statistical significance.Conclusion:Considering 2%as the critical value,the rate of PBE increasing to AECOPD patients is 29.9%,there is no dramatic correlation between PBE and the patient’s condition and clinical outcome.