Cluster Analysis Of TCM Syndrome Of Obstructive Sleep Apnea Hypopnea Syndrome With Coronary Heart Disease And Its Correlation With Serum LDL And Hs-CRP

Objective Investigate the obstructive sleep apnea hypopnea syndrome(OSAHS)merge coronary heart disease(CHD)of TCM dialectical classification by cluster analysis,and its correlation with serum low density lipoprotein(LDL)and high sensitivity C-reactive protein(hs-CRP),it can provide a reference for OSAHS combined with coronary heart disease in TCM clinical diagnosis and treatment.Methods All the basic information,symptoms and signs of OSAHS patients with coronary heart disease were input into SPSS20.0 software to establish a database.Hierarchical cluster analysis was used for cluster analysis of four diagnostic information,and submits the classification results to the expert group for discussion,to establish the TCM syndrome names of OSAHS complicated with coronary heart disease.All patients in group were measured LDL,hs-CRP,the Epworth Sleepiness Scale(ESS)score,apnea-hypopnea index(AHI),body mass index(BMI),the lowest oxygen saturation(LSaO2),and clinical indicators,severe degree were compared between each syndrome groups,besides,LDL and hs-CRP were correlated with AHI,respectively.Results 1.Essential information: In this study,70.25% of OSAHS patients with coronary heart disease were male.Women accounted for 29.75%,with an average age of 57.36±12.00 years.2.Analysis of the four diagnostic data: The five symptoms with the highest frequency of OSAHS combined with coronary heart disease are snoring,chest tightness,heartache,drowsiness and Feeling of pharyngeal obstruction.3.Cluster analysis results: The TCM syndromes of OSAHS patients with coronary heart disease are divided into: internal obstruction of phlegm and heat syndrome,pi-deficient phlegm-dampness syndrome,qi-deficiency blood-stasis syndrome and blood stasis syndrome.The main TCM syndromes are internal obstruction of phlegm-heat syndrome,followed by pi-deficient phlegm-dampness syndrome,qi-deficiency blood-stasis syndrome and blood stasis syndrome.4.Comparison of clinical indicators of each TCM syndrome:(1)BMI of internal obstruction of phlegm and heat syndrome,pi-deficient phlegm-dampness syndrome and blood stasis syndrome is higher than that of qi-deficiency blood-stasis syndrome(all P < 0.05).(2)ESS score of spleen-deficiency pi-deficient phlegm-dampness syndrome is higher than internal obstruction of phlegm and heat syndrome,qi-deficiency blood-stasis syndrome(all P < 0.05).(3)AHI of qi-deficiency blood-stasis syndrome and blood stasis syndrome is greater than internal obstruction of phlegm and heat syndrome(all P < 0.01).(4)The LDL level of pi-deficiency phlegm-dampness syndrome was higher than that of internal obstruction of phlegm and heat syndrome,qi-deficiency blood-stasis syndrome and blood stasis syndrome(all P < 0.05).(5)The hs-CRP of internal obstruction of phlegm and heat syndrome and qi deficiency and blood stasis syndrome is higher than pi-deficiency phlegm-dampness syndrome(all P < 0.01).(6)The severity of OSAHS in qi-deficiency blood-stasis syndrome and blood stasis syndrome is higher than internal obstruction of phlegm and heat syndrome(all P< 0.05).The syndromes of phlegm-heat internal obstruction and pi-deficiency phlegm-dampness are mainly mild and moderate,while the severity of qi-deficiency blood-stasis syndrome and blood stasis syndrome are mainly moderate and severe.Pairwise comparison of other syndromes showed no statistical difference(all P > 0.05).4.Correlation analysis: AHI index was positively correlated with LDL and hs-CRP(all P < 0.05).Conclusion 1.The TCM syndromes of OSAHS combined with coronary heart disease can be divided into internal obstruction of phlegm and heat syndrome,pi-deficient phlegm-dampness syndrome,qi-deficiency blood-stasis syndrome and blood stasis syndrome.The main syndromes are phlegm turbidity,qi deficiency and blood stasis,and often performance is false and real inclusion.2.The main internal obstruction of phlegm and heat syndrome and pi-deficient phlegm-dampness syndrome were mild and moderate patients,and the main qi-deficiency blood-stasis syndrome and blood stasis syndrome were moderate and severe patients.3.Compared with qi-deficiency blood-stasis syndrome is more likely to be overweight than internal obstruction of phlegm and heat syndrome,pi-deficient phlegm-dampness syndrome and blood stasis syndrome.The syndrome of pi-deficient phlegm-dampness is more prone to drowsiness than the syndrome of phlegm-heat internal obstruction and the syndrome of qi deficiency and blood stasis.4.LDL and hs-CRP are correlated with each syndrome,and increase with the aggravation of severity,which may serve as the objective basis for the clinical dialectical treatment of OSAHS complicated with coronary heart disease.