Body Mass Index Of Adolescents And Its Changes Are Closely Related With Metabolic Syndrome And Cardiovascular Risk Factors In Early Adulthood

Purpose:To investigate the influence of body mass index(BMI)and(35)BMI in adolescence on metabolic syndrome(MetS)in early adulthood.Methods:In 2010,931 middle and high-school students from 12–16 years of age were selected by stratified cluster sampling in Liaoyang City,China.Ninety-three participants from 18–23 years of age with complete baseline data were available for follow-up in July 2016.Baseline and follow-up evaluations followed the 2007 International Diabetes Federation MetS diagnostic criteria.Statistical analysis determined the relationship of MetS at follow-up with baseline BMI(BMIb),(35)BMI,and follow-up BMI(BMIf).Results:For every 1 kg/m~2 increase in BMIb,(35)BMI,and BMIf,the risk of MetS at follow-up increased 1.201-fold(95%CI:1.03–1.40),1.406-fold(95%CI:1.14–1.73),and 1.579-fold(95%CI:1.17–2.14),respectively.Receiver operating characteristic(ROC)curve analysis found that both BMIb and(35)BMI were predictive of MetS at follow-up,with area under the curve(AUC)values of 0.725 and 0.732(p<0.05) and prediction thresholds of 23.47 kg/m~2(sensitivity 70%,specificity 77.1%)and 1.95 kg/m~2(sensitivity 70%,specificity 77.1%).MetS risk was significantly higher with a high BMIb and high(35)BMI(Group 4)than with a low BMIb and low(35)BMI(Group 1;OR=230,95%CI:12.38–4270),low BMIb and high(35)BMI(Group 2),or high BMIb and low(35)BMI(Group 3;both OR=45,95%95%CI:3.353–603.99).MetS risk was higher in Groups 2 and 3 than in Group 1(p>0.05).(35)BMI was positively correlated with waist circumference(WC),systolic blood pressure(SBP),triglycerides(TG),uric acid,and glycosylated hemoglobin(HbA1c;r=0.245–0.551,p<0.05).Participants with a high BMIb and high(35)BMI had significantly higher WC,SBP,TG,HbA1c,and insulin resistance(HOMA-IR)at follow-up compared with other groups.Conclusion:Both BMI and(35)BMI in adolescence were predictive of MetS and cardiovascular risk factors in early adulthood.Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.