| Objective This researh aimed to observe the clinical efficacy of the Muda decoction flavored for liver qi stagnation and blood stasis syndrome of primary dysmenorrhea(Primary Dysmenorrhea,PD),to explore the influence of the TCM syndrome integral,Visual analog pain score(Visual Analogue Scale,VAS),uterine artery blood flow resistance index(Resistance Index,RI)and blood rheology(whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity)treated by Muda decoction flavored.Methods 60 patients with primary dysmenorrhea of liver qi stagnation and blood stasis syndrome who met the inclusion criteria were randomly divided into the treatment group and the control group with 30 patients in each group.The treatment group were given Muda decoction flavored 10 days before the monthly natural menstruation.The control groups were given Dan Curcuma Fukang decoction 10 days before the monthly natural menstruation.They both were given continuous treatment for three menstrual cycles for 14 days without stopping taking drugs during menstruation.The changes of TCM syndrome score,VAS score,uterine artery blood flow RI,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and relevant safety indexes before and after treatment in the two groups were compared,and statistical analysis was conducted.Results 1.Feasibility analysis: There was no significant difference between the two groups in age,disease course,TCM syndrome score,VAS score,uterine artery blood flow RI and hemorheology before treatment(P>0.05);2.Comparison of total efficacy of TCM syndromes: The total effective rates of TCM syndromes in the treatment group and control group were respectively 86.67% and 80.00%.The difference between the two groups was statistically significant by rank-sum test(P<0.05),indicating that the total efficacy of TCM syndromes in the treatment group was better than that in the control group,especially in improving the poor line,blood clots in the menstrual cycle and breast swelling pain.3.Comparison of TCM syndrome points and VAS points: After treatment,TCM syndrome points and VAS points in both groups were lower than those before treatment,and the decrease was more obvious in the treatment group.The difference in treatment points between the two groups was significant by rank-sum test(P<0.05),indicating that the TCM syndrome points and VAS points in treatment group were better than those in the control group.4.Comparison of uterine artery blood flow RI: After treatment,blood flow RI of left and right uterine arteries in both treatment group and control group was significantly decreased,and the blood flow RI of left and right uterine arteries was decreased more significantly in the treatment group.The difference of blood flow RI of left and right uterine arteries between the two groups was statistically significant(P<0.05).5.Comparison of hemorheology: After treatment,plasma viscosity,whole blood high-cut viscosity and whole blood low-cut viscosity of the two groups were significantly decreased compared with those before treatment(P<0.05),and the decrease was more significant in the treatment group,with statistical difference between the two groups(P<0.05).6.Safety observation: Before and after treatment,blood,urine and feces routine examination,liver and kidney function,and electrocardiogram examination of the two groups showed no obvious abnormalities,and no subjects were forced to withdraw from the study.Conclusion Muda Decoction Flavored is safe and reliable in the treatment of primary dysmenorrhea with liver qi stagnation and blood stasis,which has significant clinical efficacy and can reduce TCM syndrome score and dysmenorrhea VAS score,by reducing the uterine artery blood flow RI,improving hemorheology and correcting local tissue ischemia related,so as to alleviate the major clinical symptom of primary dysmenorrhea(menstrual abdominal pain,inhibited menstruation,darken menstruation with blood clots,breast pain). |
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