| Objective: To explore the value of cardiovascular magnetic resonance based on deformation registration algorithm(DRA)in quantitation of myocardium deformation in patients with isolated left ventricular non-compaction(i LVNC).Methods: We recruited 27 i LVNC patients(i LVNC group)and 30 healthy volunteers to undergo cardiovascular magnetic resonance on a 1.5T MR scanner.Myocardial deformation analysis was performed after cardiac cine data were imported into the strain analysis software based on DRA technique.Global and segmental strain of radial,circumferential and longitudinal direction and strain rate of systolic,early-diastole and late-diastole were semi-automatically calculated.Results: The global LS(GLS),RS(GRS)and CS(GCS)value were lower in i LVNC group than those in control group [GLS:(-11.0±3.8)% vs.(-14.3±1.8)%;GRS:(24.7±9.3)% vs(38.5±6.1)%;GCS:(-12.1±4.9)% vs.(-16.6±1.4)%;p<0.01 for all].Left ventricular ejection fration(LVEF)、stroke volume index(SVI)and cardiac index(CI)value were lower in i LVNC group than those in control group[LVEF:(42.6±14.9)% vs.(57.5±4.9)%;SVI:(28.1±8.9)ml· m﹣2 vs.(41.2±8.1)ml· m﹣2;CI:(1.8±0.6)L·min﹣1·m﹣2 vs.(2.6±0.5)L·min﹣1·m﹣2;p<0.01 for all].GRS value in EF≥50% group was lower than that in control group[(31.8±3.6)% vs(38.5±6.1)%,p<0.05].RS values in all the 16 segments were lower than those in control group(p<0.05 for all).No significant differences of CS values in the basal septum and basal inferoseptal segments were found between i LVNC group and control group(p>0.05),and the other 14 segments in i LVNC group were lower than those in control group(p<0.05 for all).LS values in apical segment and middle segment of the free wall,and in middle segment of the septal wall were lower than those in control group(p<0.05 for all).All cardiac function and myocardial deformation parameters had no significant correlation with the number of non-compacted segment(No NC)(p>0.05 for all).Conclusion: CMR-DRA technique is conducive to quantitative evaluate myocardial deformation in patients with i LVNC,and myocardial deformation permits earlier detection of LV functional impairment.Objective: To evaluate cardiovascular magnetic resonance based on deformation registration algorithm(DRA)in quantitation of left ventricular myocardium deformation in healthy volunteers in comparison with feature tracking(FT).Methods: We recruited 50 healthy volunteers to undergo cardiovascular magnetic resonance on a 1.5T MR scanner.Myocardial deformation analysis was performed after cardiac cine data were imported into the strain analysis software based on DRA and FT.Global and segmental strain of radial,circumferential and longitudinal dir ection were semi-automatically calculated.Results:(1)Global radial strain(GRS),global circumferential strain(GCS)and global longitudinal strain(GLS)measured by DRA were 38.4±7.1%,﹣ 15.9±1.5% and ﹣14.5±1.7%,respectively.GRS,GCS and GLS measured by FT were 56.9±16.4%、﹣22.5±2.6% and﹣24.4±4.7%,respectively.The global strain values measured by two methods had notable correlation(GRS: r=0.61,GCS: r=0.39,GLS: r=0.70,respectively).(2)Mean differences with 95% confidence intervals of GRS,GCS and GLS values measured by DRA and FT were﹣18.58(﹣48.18,11.02)、6.54(2.77,10.31)、8.8(4.35,13.26).(3)GRS,GCS,GLS measured by DRA and GCS,GLS measured by FT had good observer agreement evaluated by ICC(all larger than 84%).Intraobserver and interobserver agreement of GRS measured by FT were not good(intra:0.39,inter:0.51).(4)ICC of RS values in 16 segments: DRA(intraobserver variability range: 0.69-0.99,interobserver variability range: 0.71-0.98),FT(intra: 0.02-0.80,inter: 0.01-0.75);ICC of CS values in 16 segments: DRA(intra: 0.84-0.98,inter: 0.77-0.99),FT(: 0.55-0.91,inter: 0.58-0.93);ICC of LS values in 6 segments: DRA(intra: 0.92-0.99,inter: 0.94-0.99),FT(intra: 0.71-0.96,inter: 0.56-0.94).Conclusion: Both DRA and FT can evaluate the left ventricular myocardial strain,and the global strains have good correlation;DRA and FT have good consistency with GCS and GLS;The reproducibility of segmental strain measured by DRA is better than that measured by FT. |
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