Prognosis Related Risk Fcactors Of Neonatal Necrotizing Enterocolitis In Neonates

Objective: To explore the risk factors related to the prognosis of neonatal necrotizing enteroeolitis(NEC)in preterm infants and full term infants.Methods: Clinical data of 341 patients diagnosed as NEC(Bell ’ s stage ≥ Ⅱ)during January 2010 and January 2018 were retrospectively analyzed.According to the gestational age,patients were divided into preterm infant’s group and full term infant’s group.The risk factors of prognosis were compared and analyzed.Results: A total of 341 neonates with Bell’s stage ≥ Ⅱ NEC were enrolled.144 preterm infants were enrolled,104 patients were cured,and40 were dead.197 full term neonates were included: 169 were cured,and28 were dead.Logistic analysis showed that respiratory failure(OR: 3.521,95%CI: 1.349,9.194,p=0.010),and immunoglobulin transfusion post NEC(OR: 5.060,95%CI: 1.977,12.953,p=0.001)were the main risk factors in preterm neonates with NEC.Sepsis post NEC,NEC with Bell’s stage Ⅲ,onset day of NEC and first fasting time post NEC were the factors related to the prognosis in full term NEC neonates.Conclusion: The risk factors of NEC between the preterm infants and full term infants were different.Preterm infants related to respiratory failure,and immunoglobulin transfusion.Full term infants were correlated with onset time of NEC,NEC with Bell’s stage Ⅲ,sepsis and first fasting time after NEC.The active prevention and cure of infection,pay more attention to those preterm infants who received immunoglobulin transfusion and early onset day of NEC in full term infants may reduce the fatality rate of NEC.