Effects Of Balance Training On Patients With Chemotherapy-induced Peripheral Neuropathy

Objective: To explore the effect of balance training on the symptoms,activities of daily living,quality of life and physical activity levels of patients with chemotherapy-induced peripheral neuropathy,and to determine its safety and feasibility,so as to provide reference for the intervention of chemotherapy-induced peripheral neuropathy.Methods: A randomized controlled trial was conducted for this study.A total of 46 patients with chemotherapy-induced peripheral neuropathy were recruited in a third-grade class-A hospital in Shijiazhuang city from July 2018 to October 2018,and randomly divided into the intervention group and the control group according to 1:1.Patients in the control group were given routine nursing,and those in the intervention group were given balance training for 12 weeks besides routine nursing.SPSS software was used for intra-group and inter-group comparison of the symptoms,activities of daily living of patients with chemotherapy-induced peripheral neuropathy,and inter-group comparison of the quality of life and physical activity levels of patients in two groups.Results: A total of 38 patients completed the whole study,including 18 cases in the intervention group and 20 cases in the control group,without any exercise-related adverse events.The results showed that(1)there were no significant differences in the general information,symptoms,activities of daily living,quality of life and physical activity levels of the patients with chemotherapy-induced peripheral neuropathy between two groups before the trial(P>0.05);(2)after the trial,the symptoms of sensory neuropathy of lower extremities alleviated in the intervention group compared with those before trial,and the differences were statistically significant(P < 0.05),while there were no obvious changes in the control group(P>0.05),and the differences between groups were significant(P < 0.05);(3)after the trial,the symptoms of chemotherapy-induced peripheral neuropathy and its effect on activities of daily living of the patients in the intervention group was less than those before trial,and the difference was statistically significant(P<0.05),while there was no significant changes in the control group(P> 0.05),but the differences between two groups were not statistically significant(P>0.05);(4)after the trial,patients’ emotional function and quality of life in the intervention group were better than those in the control group,with statistically significant differences(P < 0.05);(5)after the trial,there was no significant differences in the physical activity levels between two groups(P>0.05).Conclusions: The intensity,frequency,time and difficulty of balance training designed in this study are safe and feasible for patients with chemotherapy-induced peripheral neuropathy.12-week balance training can improve the symptoms of sensory neuropathy of lower extremities,patients’ emotional function and quality of life.