Relationship Between Apolipoprotein AI,Apolipoprotein B And Cerebral Infarction And Carotid Plaque

Objective: Cerebral infarction is a disease that seriously threatens the lives and health of our residents.It accounts for a large proportion of ischemic cerebrovascular diseases.In recent years,its incidence has increased significantly along with economic development and has increasingly attracted the attention of all sectors of society.The main cause of carotid atherosclerosis has attracted increasing attention.This study aims to explore the relationship between apolipoprotein AI,apolipoprotein B and the formation of carotid plaque and cerebral infarction,and to verify whether they are protective factors and risk factors of cerebral infarction respectively,and whether they are related to the formation of carotid plaque.It provides a theoretical basis for prevention and treatment of carotid atherosclerosis and cerebral infarction.Methods:1.Research object:Case group: 130 patients with acute cerebral infarction who were admitted to the Department of Encephalopathy,Changcheng Hospital,Shijiazhuang,from December 2016 to December 2017.The age of onset should be 35-85 years old;the responsible lesions should be determined by CT or MR;the diagnostic criteria for cerebral infarction in accordance with the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2014(full version).Control group: 80 cases,from December 2016 to December 2017,Shijiazhuang Great Wall Hospital outpatients aged 35-85 years old health checkups.2.Implementation plan: All selected patients underwent carotid Doppler ultrasound examination.The case group performed head CT or MR to determine the responsible lesion.The study was approved by the Ethics Committee of the Great Wall Hospital of Shijiazhuang City,and all selected personnel signed informed consent.Case group: According to the results of color Doppler ultrasound,there were plaques in cerebral infarction group A and no plaque in cerebral infarction group B.At the same time,cerebral infarction group A was divided into stable plaque group and unstable plaque group according to the nature of plaque..Control group: According to the results of color ultrasound can be divided into: plaque group and no plaque group;plaque group is divided into stable plaque group,unstable plaque group.3.Requirements: Comparing the composition ratio of age and gender,there was no significant difference between group A and group B and control group(P>0.05).4.Data processing: 1 Observe the biochemical indicators of the case group and the control group and compare them.2 Observe the various biochemical indicators of group A and group B in the case group and compare them.3 Observe the ratios of case groups to control groups and compare them.4 Observe case group A.Apolipoprotein AI and apolipoprotein B levels in various plaques.5 Effects of various traditional factors on apolipoprotein AI and apolipoprotein B levels.6 Spearman et al.used Spearman et al.to analyze the relationship between multiple factors and carotid plaque formation and cerebral infarction,and gradually performed logistic regression analysis and likelihood ratio test.Finally,the conclusion was reached.Result:1.Case group and control group: The former had significantly higher systolic blood pressure,blood glucose,apolipoprotein B,and cholesterol(P < 0.01);the former had higher triglyceride,lower LDL cholesterol than the latter(P < 0.05);The former had significantly lower apolipoprotein AI levels than the latter(P < 0.01);the former had lower HDL cholesterol than the latter(P < 0.05);the former was associated with fibrinogen,uric acid,and homocysteine.There was no difference in acid levels(P>0.05).2.The cerebral infarction group A and cerebral infarction group B: The former had significantly higher levels of apolipoprotein B and blood glucose(P < 0.01);the former had higher triglyceride,cholesterol,and low-density lipoprotein cholesterol levels than the latter(P < 0.05);The former had lower levels of high-density lipoprotein cholesterol than the latter(P < 0.05);the former had significantly lower levels of apolipoprotein AI than the latter(P < 0.01);the former and the latter had systolic blood pressure,homocysteine,There was no significant difference in fibrinogen and uric acid levels(P> 0.05).3.Case group A: The level of apolipoprotein B in the stable plaque group was significantly lower than that in the unstable plaque group(P < 0.01);the level of apolipoprotein AI in the stable plaque group was significantly higher than that in the unstable plaque group(P < 0.01).4.Multivariate regression analysis was performed in parallel.The results showed that Apolipoprotein AI(ApoAI)and Apolipoprotein B(ApoB)levels were protective factors and risk factors for cerebral infarction(ApoAI: OR=0.204,95).%CI 0.067～0.619;ApoB: OR=3.923,95% CI 1.038～14.834,P < 0.05),which are also protective factors and risk factors for carotid plaque formation in patients with cerebral infarction(ApoAI: OR=0.235,95%)CI 0.081～0.684;ApoB: OR=4.477,95% CI 1.228～16.327,P < 0.05).5.The levels of Apo-AI and Apo-B are affected by many factors such as blood pressure,blood glucose,blood lipids,and alcohol(≥200g daily) nd tobacco habits(≥20 daily).This study confirmed that: hypertension,elevated blood glucose,low-density lipoprotein,smoking,drinking can lead to decreased ApoAI levels(P <0.05);hypertension,elevated blood sugar,low-density lipoprotein,smoking can lead to increased ApoB levels(P < 0.05).Conclusion:In addition to traditional risk factors,apolipoprotein AI and apolipoprotein B may be considered as protective and risk factors for atherosclerosis,respectively,and are associated with carotid atherosclerosis and plaque formation,controlling blood lipids,and preventing carotid atherosclerosis.Sclerotherapy,and then block to avoid the occurrence of cerebral infarction.Apolipoprotein AI,apolipoprotein B levels are affected by a variety of factors.