Potential Correlation Analysis Of Carotid Plaque And Blood Pressure Variability In Treated Hypertensive Patients With Normal Blood Pressure

Objective:The aim of this study was to investigate the relationship between 24 h variation of blood pressure(BP)and carotid plaque in treated hypertensive patients with normal blood pressure.Methods:From July 1,2017 to solstice September 5,2018,190 consecutive cases of conventional treated essential hypertension patients(EH)with normal systolic blood pressure(SBP)and diastolic blood pressure(DBP)were collected in the hypertension clinic and inpatient department of the First Hospital of Shanxi Medical University,exclusion criteria included people younger than 18 or older than 90,pregnant women,secondary hypertension and night workers.Cervical vascular ultrasound and 24-hour ambulatory blood pressure monitoring(ABPM)was used for assessment,according to the thickness of each plaque was at least 0.5mm or not,all patients were divided into the "plaque" group(n=123)and the "non-plaque" group(n=67),Calculate mean blood pressure level,mean pulse pressure difference level,blood pressure variability(blood pressure variability,BPV)parameters according to ambulatory blood pressure monitoring report: blood pressure night drop rate,standard deviation(standard deviation,SD),coefficient of variation(coefficient of variation,CV)),according to the individual SBPchanges,grouping patients’ blood pressure circadian rhythm into sputum type(SBP nighttime blood pressure drop 10-20%)group and non-sacral shape(SBP nighttime blood pressure drop <10%)group.Logistic regression analysis of carotid plaque and dynamic pressure monitoring variables The relationship between.Results:1.A total of 184 patients with hypertension receiving treatment were enrolled,including 103 males(55.98%)and 81 females(44.02%),with an overall mean age of56.99 13.84 years.2.Univariate analysis results:The age,body mass index(BMI),diabetes(DM),family history of hypertension,and blood pressure were statistically significant(P<0.05)in the general data.24-hour mean diastolic blood pressure(24h-DBP),24-hour mean diastolic blood pressure coefficient of variation(24h-DCV),daytime mean diastolic blood pressure(d-DBP),nighttime mean systolic blood pressure(n-SBP),nocturnal systolic blood pressure coefficient of variation(n-SCV),nighttime diastolic blood pressure coefficient of variation(n-DCV),morning average diastolic blood pressure(MDBP),SBP nighttime decline rate(SBPD%),DBP nighttime decline rate(DBPD%),non-squat blood pressure pattern in each The difference between the groups was statistically significant(P<0.05).Patients with non-dipper blood pressure were more likely to have carotid plaques than patients with sputum blood pressure(P<0.001).3.Correlation analysis: carotid artery plaque was associated with age(r=0.593,P <0.001)and DM(r=0.509,P < 0.001)in general data.Among the parameters for dynamic blood pressure monitoring,carotid plaque was associated with 24h-dbp(r=0.593,P <0.001),24h-dsd(r=-0.394,P < 0.001),24h-dcv(r=-0.218,P=0.002),d-dbp(r=-0.397,P <0.001),n-sbp(r=0.312,P < 0.001),n-scv(r=-0.200,P=0.006),n-dsd(r=-0.187,P=0.010),n-dcv(r=-0.204,P=0.005),MDBP(r=-0.266,P < 0.001),SBPD%(r=-0.409,P < 0.001),DBPD%(r=-0.471,P < 0.001),non-scoop blood pressure pattern(r=0.573,P < 0.001)were correlated.4.The Logistic analysis showed that: in carotid plaques for the dependent variable,age,diabetes and ambulatory blood pressure monitoring variables as independent variables,binary linear regression analysis,in addition to the age(P < 0.001),a scoop shape model of blood pressure(OR = 2.000,95% CI: 2.000-2.016,P < 0.001),24 h-DCV(OR =1.267,95% CI: 1.123-1.581,P = 0.001)and control good carotid plaques related patients with essential hypertension.Conclusion:In well-controlled patients with essential hypertension,increased non-arytenoid blood pressure pattern and 24-hour diastolic blood pressure coefficient of variation increased may be risk factors for carotid artery plaque formation.